{"id":"W4310055676","doi":"10.1093/braincomms/fcac309","title":"Cerebrospinal fluid biomarkers for assessing Huntington disease onset and severity","year":2022,"lang":"en","type":"article","venue":"Brain Communications","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada; BC Children's Hospital; University of British Columbia","funders":"Canadian Institutes of Health Research; Huntington Society of Canada","keywords":"Huntington's disease; Disease; Biomarker; Receiver operating characteristic; Cerebrospinal fluid; Medicine; Mutation; Internal medicine; Oncology; Biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001832657,0.0008048375,0.0005579343,0.002036464,0.0003252215,0.0006899498,0.0002891126,0.0005878421,0.0007464735],"category_scores_gemma":[0.002298687,0.0002059685,0.0002707441,0.0008253858,0.0003070713,0.0004891929,0.0004073032,0.0005670894,0.0002385074],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002585699,"about_ca_system_score_gemma":0.0003462389,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009511671,"about_ca_topic_score_gemma":0.001311205,"domain_scores_codex":[0.999398,0.0001884556,0.00009201442,0.0001202052,0.0001580355,0.00004339809],"domain_scores_gemma":[0.9988126,0.000409589,0.000384373,0.00006076955,0.0001963619,0.0001363833],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001483876,0.0001786066,0.8790066,0.0002284932,0.0002353411,0.0004573064,0.0002227417,0.000696208,0.05669092,0.0001649902,0.0007223952,0.05991247],"study_design_scores_gemma":[0.00008476605,0.002049836,0.9701809,0.0001190325,0.0001971247,0.002301728,0.0002904114,0.003145172,0.01893369,0.0004653054,0.002186906,0.00004518778],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9843338,0.007921984,0.004442798,0.0001656694,0.00006150668,0.0001855951,0.001212599,0.0001477067,0.001528374],"genre_scores_gemma":[0.9844306,0.002315163,0.01138197,0.000139064,0.00008589197,0.0001154141,0.0008251171,0.00001316499,0.0006936146],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002036464,"threshold_uncertainty_score":0.009692192,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06496158237334536,"score_gpt":0.3380933001751689,"score_spread":0.2731317178018235,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}