{"id":"W4310058921","doi":"10.1038/s41467-022-34895-1","title":"Defective activation and regulation of type I interferon immunity is associated with increasing COVID-19 severity","year":2022,"lang":"en","type":"article","venue":"Nature Communications","topic":"COVID-19 Clinical Research Studies","field":"Medicine","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Advancing Translational Sciences; Mercatus Center, George Mason University; Health Service Executive; Institut des maladies génétiques Imagine; Ministère de l'Enseignement supérieur, de la Recherche et de l'Innovation; National Institute of Allergy and Infectious Diseases; National Center for Research Resources; Fisher Center for Alzheimer's Research Foundation; Agence Nationale de la Recherche; Wellcome Trust; European Commission; Fondation pour la Recherche Médicale; Canadian Institute for Theoretical Astrophysics; Institut Pasteur; Institut National de la Santé et de la Recherche Médicale; Fondation du Souffle; JPB Foundation; Science Foundation Ireland; Health Research Board; St. Giles Foundation; George Mason University; National Institutes of Health; Georgia Clinical and Translational Science Alliance; Howard Hughes Medical Institute","keywords":"Interferon; Immunology; Autoantibody; Medicine; Asymptomatic; Immune system; ARDS; Virology; Antibody; Lung; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002883476,0.0002692293,0.0003158245,0.0004591087,0.0001903629,0.000408583,0.0001196031,0.0002728319,0.001768394],"category_scores_gemma":[0.0008037983,0.0001335702,0.0001984961,0.0004033329,0.000211594,0.0001710523,0.0003274522,0.0004970211,0.0002374763],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000174881,"about_ca_system_score_gemma":0.0001237706,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003279311,"about_ca_topic_score_gemma":0.0003248308,"domain_scores_codex":[0.9997273,0.00006519745,0.00003532147,0.00007135447,0.00005005321,0.00005077331],"domain_scores_gemma":[0.9990201,0.00008447611,0.0005648665,0.00005455015,0.00008201772,0.0001940155],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002943563,0.0001820792,0.7586662,0.0001326472,0.00009760835,0.0006461678,0.0001793135,0.00009615393,0.2258744,0.00008518489,0.0002267121,0.01086997],"study_design_scores_gemma":[0.000008926851,0.0006112703,0.9911992,0.000009497709,0.00001818623,0.0007741597,0.00009539897,0.00009952473,0.00682095,0.00004278302,0.000315717,0.000004351064],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983826,0.0005405301,0.000312031,0.00003718999,0.000006480735,0.00001687103,0.0002267579,0.00001029212,0.0004673254],"genre_scores_gemma":[0.9988703,0.0002371754,0.0002808513,0.00003345266,0.000009436971,0.000009612982,0.0003479072,0.000003179508,0.0002081921],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001768394,"threshold_uncertainty_score":0.005915821,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06745434112606884,"score_gpt":0.4316805232108467,"score_spread":0.3642261820847778,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}