{"id":"W4310058945","doi":"10.1038/s41467-022-34961-8","title":"Induction of cross-neutralizing antibodies by a permuted hepatitis C virus glycoprotein nanoparticle vaccine candidate","year":2022,"lang":"en","type":"article","venue":"Nature Communications","topic":"Hepatitis C virus research","field":"Medicine","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Institute of Infection and Immunity; National Institutes of Health; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Amsterdam University Medical Centers; AstraZeneca; National Institute of Allergy and Infectious Diseases; Bill and Melinda Gates Foundation","keywords":"Virology; Neutralizing antibody; Neutralization; Antibody; Glycoprotein; Epitope; Hepatitis C virus; Recombinant DNA; Ebola virus; Virus; Biology; Immunology; Molecular biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001487068,0.000297428,0.0001472024,0.0001118058,0.00008124793,0.0001931352,0.0001506366,0.0003155187,0.0005358819],"category_scores_gemma":[0.0001248574,0.0001179182,0.000197004,0.00006624404,0.0001322814,0.00015704,0.0001709448,0.0003304897,0.0001594114],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000241643,"about_ca_system_score_gemma":0.000132423,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002469175,"about_ca_topic_score_gemma":0.0003842946,"domain_scores_codex":[0.9999073,0.00001892025,0.000006542212,0.00002350737,0.0000241745,0.00001954114],"domain_scores_gemma":[0.9999522,0.000008012019,0.00001281449,0.000005492519,0.00001075576,0.00001074611],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003053452,0.00002117096,0.00005461695,0.00001656404,0.000003735368,0.00002611529,0.000005916073,0.0001869405,0.998449,0.0001316438,0.00003299283,0.001040782],"study_design_scores_gemma":[0.00001970582,0.0005667402,0.0005078986,0.000004005757,0.00001038558,0.0001994801,0.00000800643,0.002898251,0.9936898,0.00005573833,0.002035666,0.000004355014],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9831542,0.0009810639,0.01338488,0.0001311604,0.00006335454,0.0000664081,0.00008979456,0.00009165838,0.002037261],"genre_scores_gemma":[0.9864574,0.0004536517,0.01086912,0.0001085356,0.000009316277,0.00004015214,0.0001795257,0.00001543308,0.001866933],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005358819,"threshold_uncertainty_score":0.001792669,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03277355893182842,"score_gpt":0.3780818603874813,"score_spread":0.3453083014556528,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}