{"id":"W4310058945","doi":"10.1038/s41467-022-34961-8","title":"Induction of cross-neutralizing antibodies by a permuted hepatitis C virus glycoprotein nanoparticle vaccine candidate","year":2022,"lang":"en","type":"article","venue":"Nature Communications","topic":"Hepatitis C virus research","field":"Medicine","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Institute of Infection and Immunity; National Institutes of Health; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Amsterdam University Medical Centers; AstraZeneca; National Institute of Allergy and Infectious Diseases; Bill and Melinda Gates Foundation","keywords":"Virology; Neutralizing antibody; Neutralization; Antibody; Glycoprotein; Epitope; Hepatitis C virus; Recombinant DNA; Ebola virus; Virus; Biology; Immunology; Molecular biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004344844,0.0001287581,0.0002768499,0.000201251,0.0007194577,0.00003324581,0.0006172031,0.0001336789,0.000416829],"category_scores_gemma":[0.0003714662,0.000133789,0.00008281307,0.0008549911,0.0001707112,0.0001780751,0.0006603148,0.001461476,0.00001420527],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002325034,"about_ca_system_score_gemma":0.0001750739,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006508049,"about_ca_topic_score_gemma":0.003706649,"domain_scores_codex":[0.9982853,0.0003253113,0.0003953663,0.0002233079,0.0004959779,0.0002747504],"domain_scores_gemma":[0.9977125,0.000119538,0.0001488274,0.001549609,0.0003580925,0.0001114663],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001463214,0.0004923062,0.3489995,0.00004358237,0.00009950587,0.000008315642,0.0006042758,0.0000146507,0.6344786,0.000999409,0.01112989,0.002983605],"study_design_scores_gemma":[0.003080754,0.0007069682,0.3467451,0.00009930192,0.000122017,0.00009099705,0.0002875783,0.002579577,0.3889688,0.0001801048,0.256756,0.0003827101],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9858841,0.006365302,0.000009635773,0.005166201,0.00009688493,0.0006234735,0.0004805081,0.00008823571,0.001285691],"genre_scores_gemma":[0.9948301,0.002432949,0.001109206,0.0003515203,0.00002514941,0.0002332497,0.000569802,0.00003149522,0.0004164795],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2456261,"threshold_uncertainty_score":0.9838266,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03277355893182842,"score_gpt":0.3780818603874813,"score_spread":0.3453083014556528,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}