{"id":"W4310082281","doi":"10.1002/psp4.12886","title":"Delineating gene–environment effects using virtual twins of patients treated with clozapine","year":2022,"lang":"en","type":"article","venue":"CPT Pharmacometrics & Systems Pharmacology","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Libin Cardiovascular Institute of Alberta; Alberta Children's Hospital; University of Calgary","funders":"","keywords":"Covariate; Clozapine; Statistics; Virtualization; Gene–environment interaction; Schizophrenia (object-oriented programming); Computer science; Econometrics; Psychology; Genotype; Mathematics; Biology; Psychiatry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007458527,0.0003090116,0.0005487834,0.0004534571,0.0003196063,0.00000850498,0.0003676623,0.0001284248,0.0001107244],"category_scores_gemma":[0.00008473104,0.0003008369,0.0001273098,0.000843009,0.00009970252,0.000006193471,0.0004179743,0.0002571074,0.000005052557],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000233645,"about_ca_system_score_gemma":0.0001061972,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008990869,"about_ca_topic_score_gemma":4.392444e-7,"domain_scores_codex":[0.9969143,0.0009102894,0.000725663,0.0005630356,0.0003545179,0.000532168],"domain_scores_gemma":[0.9985354,0.0001731514,0.000688179,0.0002565778,0.0001811125,0.0001655699],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003029138,0.0006286993,0.3002255,0.00006629866,0.0006162356,0.00001361208,0.00005032202,0.1347162,0.5594981,0.000006066706,0.002596289,0.001279793],"study_design_scores_gemma":[0.0417433,0.01535904,0.1121194,0.0000395492,0.003014333,0.0002648917,0.0006746318,0.1436106,0.5111895,0.000007397678,0.1689547,0.003022712],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885476,0.002311558,0.006889737,0.00002278283,0.00106876,0.0008752317,0.0002116646,0.00002004294,0.00005259056],"genre_scores_gemma":[0.9971845,0.0003229588,0.0008826065,0.0003576424,0.0003254141,0.0002296555,0.0004461781,0.00005877922,0.0001923389],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1881061,"threshold_uncertainty_score":0.9999444,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01712920626332373,"score_gpt":0.2800405349078978,"score_spread":0.2629113286445741,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}