{"id":"W4310082281","doi":"10.1002/psp4.12886","title":"Delineating gene–environment effects using virtual twins of patients treated with clozapine","year":2022,"lang":"en","type":"article","venue":"CPT Pharmacometrics & Systems Pharmacology","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Libin Cardiovascular Institute of Alberta; Alberta Children's Hospital; University of Calgary","funders":"","keywords":"Covariate; Clozapine; Statistics; Virtualization; Gene–environment interaction; Schizophrenia (object-oriented programming); Computer science; Econometrics; Psychology; Genotype; Mathematics; Biology; Psychiatry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001571271,0.0003739079,0.0005050352,0.000358418,0.0003790028,0.0005150192,0.0005330686,0.0004184924,0.001379411],"category_scores_gemma":[0.004903146,0.0004610427,0.001175407,0.0002767457,0.0004321898,0.0002878971,0.0006590604,0.0005144123,0.0001358185],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000760066,"about_ca_system_score_gemma":0.000896176,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02157681,"about_ca_topic_score_gemma":0.01473331,"domain_scores_codex":[0.9994667,0.0003212596,0.00002642787,0.0001002709,0.00004230425,0.00004297414],"domain_scores_gemma":[0.9980097,0.001238075,0.0002189619,0.000278908,0.0001459557,0.0001084208],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.002629497,0.0004129377,0.4073323,0.00006182946,0.0009471724,0.0007302406,0.0003614336,0.5491183,0.01359325,0.003144087,0.0005970204,0.02107193],"study_design_scores_gemma":[0.0001070733,0.0005039542,0.06030299,0.000007973741,0.0002144888,0.0003777889,0.0001569633,0.9304241,0.005139061,0.002128833,0.0006001637,0.0000366442],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922076,0.00001541367,0.007321627,0.00002924614,0.000004376501,0.00001500277,0.0002214549,0.00003215541,0.0001532192],"genre_scores_gemma":[0.9947183,0.00001444187,0.004682647,0.00001384275,0.000001723658,0.00001632936,0.0004136037,0.00001020919,0.0001290045],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02157681,"threshold_uncertainty_score":0.04290241,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01712920626332373,"score_gpt":0.2800405349078978,"score_spread":0.2629113286445741,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}