{"id":"W4310082819","doi":"10.1002/alz.12867","title":"Functional network segregation is associated with attenuated tau spreading in Alzheimer's disease","year":2022,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Functional Brain Connectivity Studies","field":"Neuroscience","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; Deutsche Forschungsgemeinschaft; Northern California Institute for Research and Education; Pfizer; Novartis Pharmaceuticals Corporation; University of Southern California; Biogen; Eli Lilly and Company; Bristol-Myers Squibb; BioClinica; U.S. Department of Defense; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics; National Institute on Aging; Alzheimer's Association","keywords":"Neuroscience; Tau pathology; Resting state fMRI; Functional magnetic resonance imaging; Alzheimer's disease; Entorhinal cortex; Alzheimer's Disease Neuroimaging Initiative; Psychology; Cognitive decline; Functional connectivity; Human Connectome Project; Disease; Cognitive impairment; Cognition; Dementia; Medicine; Internal medicine; Hippocampus","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003032445,0.0002804333,0.0002292989,0.0007232726,0.0002203272,0.000385078,0.0001751667,0.0002404064,0.001150417],"category_scores_gemma":[0.001486719,0.0001405838,0.0001500663,0.0003629996,0.0002312338,0.0003732718,0.0003182434,0.0001848348,0.00008779152],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002730982,"about_ca_system_score_gemma":0.000109366,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001281727,"about_ca_topic_score_gemma":0.002336833,"domain_scores_codex":[0.9999038,0.00002628221,0.000007213539,0.00003183555,0.00001592648,0.000014888],"domain_scores_gemma":[0.9993513,0.0001452739,0.0003206413,0.00004949431,0.00006127606,0.00007204278],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002986317,0.000258758,0.820815,0.0001682092,0.0006448682,0.0008080758,0.0008501723,0.003920386,0.1332882,0.0009707013,0.0006567003,0.03463265],"study_design_scores_gemma":[0.00001258888,0.000108649,0.9927886,0.000007920164,0.00007078648,0.0005607837,0.00007106502,0.002837788,0.002319896,0.001084819,0.0001310717,0.000006115152],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985391,0.0001201283,0.0009198629,0.00003356145,0.000001219753,0.00000453392,0.00008207195,0.00001091229,0.0002886063],"genre_scores_gemma":[0.9992495,0.00005214367,0.0004626761,0.000006587207,0.000003051748,0.000005792487,0.0001242988,0.000003358354,0.00009244154],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001281727,"threshold_uncertainty_score":0.003848553,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04771791477785858,"score_gpt":0.2514136507943211,"score_spread":0.2036957360164625,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}