{"id":"W4310089979","doi":"10.1371/journal.ppat.1010999","title":"High-density binding to Plasmodium falciparum circumsporozoite protein repeats by inhibitory antibody elicited in mouse with human immunoglobulin repertoire","year":2022,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Trypanosoma species research and implications","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"Canadian Institutes of Health Research; Hospital for Sick Children; Bill and Melinda Gates Foundation; Office of Science; National Institutes of Health; Canada Research Chairs; National Cancer Institute; Bloomberg Philanthropies; National Institute of General Medical Sciences; Canadian Institute for Advanced Research; Argonne National Laboratory; U.S. Department of Energy","keywords":"Circumsporozoite protein; Plasmodium falciparum; Antibody; Epitope; Biology; Monoclonal antibody; Virology; Antigen; Affinity maturation; Molecular biology; Malaria; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001253465,0.0003032026,0.0005149469,0.0005510539,0.0007117342,0.0000509916,0.0003049214,0.00009771389,0.0002784876],"category_scores_gemma":[0.0001790588,0.0002918316,0.00009667814,0.001159675,0.0001053886,0.0001254373,0.000357815,0.0007533371,0.00008443114],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007092479,"about_ca_system_score_gemma":0.0002184322,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005273655,"about_ca_topic_score_gemma":0.0001047516,"domain_scores_codex":[0.9967178,0.0001749665,0.0005311976,0.0008038305,0.0009710524,0.0008011856],"domain_scores_gemma":[0.998189,0.00003146597,0.0001450615,0.001047979,0.00017371,0.000412774],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004850161,0.0009767846,0.016211,0.00005558885,0.00006047263,0.000410845,0.0004617002,0.00001611317,0.9791268,0.00009304853,0.001862271,0.0002404222],"study_design_scores_gemma":[0.003915573,0.002710105,0.1985314,0.0002658951,0.00007060021,0.0002179059,0.001390037,0.00006083472,0.7850232,0.00002964276,0.007044725,0.0007401585],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994672,0.00008966081,0.00003147777,0.001522469,0.00003818108,0.002199898,0.0008561946,0.000220123,0.000370003],"genre_scores_gemma":[0.992408,0.00001151735,0.0005996494,0.0003345186,0.00009339321,0.0007478055,0.001224425,0.00008735701,0.004493293],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1941036,"threshold_uncertainty_score":0.9999534,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01912109142460935,"score_gpt":0.2756340982334839,"score_spread":0.2565130068088746,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}