{"id":"W4310089979","doi":"10.1371/journal.ppat.1010999","title":"High-density binding to Plasmodium falciparum circumsporozoite protein repeats by inhibitory antibody elicited in mouse with human immunoglobulin repertoire","year":2022,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Trypanosoma species research and implications","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"Canadian Institutes of Health Research; Hospital for Sick Children; Bill and Melinda Gates Foundation; Office of Science; National Institutes of Health; Canada Research Chairs; National Cancer Institute; Bloomberg Philanthropies; National Institute of General Medical Sciences; Canadian Institute for Advanced Research; Argonne National Laboratory; U.S. Department of Energy","keywords":"Circumsporozoite protein; Plasmodium falciparum; Antibody; Epitope; Biology; Monoclonal antibody; Virology; Antigen; Affinity maturation; Molecular biology; Malaria; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001636013,0.0005423191,0.0001919692,0.0003270476,0.0001280796,0.0002257786,0.0003121515,0.0004086815,0.001501249],"category_scores_gemma":[0.00006974455,0.0002157967,0.0002768349,0.0001246882,0.0001542154,0.0001394321,0.0001627373,0.0008938365,0.0004680984],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003387226,"about_ca_system_score_gemma":0.0001459447,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00071515,"about_ca_topic_score_gemma":0.001067306,"domain_scores_codex":[0.9997825,0.00002692346,0.00001229455,0.00005468088,0.00004503596,0.00007857304],"domain_scores_gemma":[0.9999466,0.000008281032,0.0000115551,0.000007236779,0.000006859928,0.0000193516],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006777479,0.00005180723,0.0001509297,0.00001902566,0.000004840803,0.00002701823,0.000009612226,0.00005354616,0.9984965,0.00007769248,0.00005496579,0.0009862285],"study_design_scores_gemma":[0.00004964667,0.001012673,0.005993957,0.00001761938,0.00004134332,0.0004772812,0.0000233545,0.003005409,0.9846237,0.00009971539,0.00464974,0.000005622677],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9887499,0.001657672,0.004792756,0.0001638646,0.0000258397,0.00006113194,0.0003241021,0.0001998901,0.004024809],"genre_scores_gemma":[0.9914945,0.001106241,0.002680711,0.0001673823,0.00001905098,0.00006192211,0.0006461293,0.0000256835,0.003798333],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001501249,"threshold_uncertainty_score":0.005022228,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01912109142460935,"score_gpt":0.2756340982334839,"score_spread":0.2565130068088746,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}