{"id":"W4310093492","doi":"10.1182/blood-2022-168675","title":"The Empower Study - Design of a Randomized Clinical Trial to Assess the Efficacy and Safety of a Plasma-Derived Von Willebrand Factor / Factor VIII Concentrate for Heavy Menstrual Bleeding in Women with Von Willebrand Disease","year":2022,"lang":"en","type":"article","venue":"Blood","topic":"Myeloproliferative Neoplasms: Diagnosis and Treatment","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Queen Elizabeth II Health Sciences Centre; University of Alberta; Queen's University; St. Paul's Hospital; Health Sciences Centre; University of Toronto; St. Michael's Hospital","funders":"","keywords":"Medicine; Von Willebrand disease; Von Willebrand factor; Randomized controlled trial; Placebo; Crossover study; Menstruation; Clinical trial; Pediatrics; Internal medicine; Obstetrics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01382051,0.003376134,0.006306808,0.0008556475,0.0008814277,0.00170641,0.001686412,0.003645183,0.01261224],"category_scores_gemma":[0.01277808,0.001242593,0.003284992,0.0007337742,0.002751027,0.002244888,0.001262995,0.003600536,0.001854563],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001144476,"about_ca_system_score_gemma":0.003134839,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006145765,"about_ca_topic_score_gemma":0.001084392,"domain_scores_codex":[0.9906934,0.006990169,0.0004815086,0.0008817641,0.0003831263,0.0005701317],"domain_scores_gemma":[0.9932346,0.002868218,0.001387023,0.0007746513,0.000532538,0.001203039],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9897531,0.004773169,0.0004298869,0.000512868,0.0006198688,0.0000242872,0.0000366543,0.0001807253,0.0005707521,0.0002526215,0.0004522237,0.002393856],"study_design_scores_gemma":[0.9396386,0.05823081,0.0004320231,0.0000413591,0.0003401576,0.00001260277,0.00001398574,0.0002471037,0.0001335502,0.0002511116,0.0006470848,0.00001156761],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"protocol","genre_scores_codex":[0.7090901,0.005349305,0.007026981,0.00210723,0.003656082,0.259789,0.005670278,0.0005348086,0.006776131],"genre_scores_gemma":[0.5948517,0.002491836,0.01989036,0.003807749,0.002433342,0.3644184,0.002840167,0.00009780712,0.009168723],"genre_candidate":"protocol","genre_consensus":null,"teacher_disagreement_score":0.01382051,"threshold_uncertainty_score":0.07309073,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0504650170704808,"score_gpt":0.331584281593129,"score_spread":0.2811192645226482,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}