{"id":"W4310093519","doi":"10.1182/blood-2022-157011","title":"CD19 4-1BBL (RO7227166) a Novel Costimulatory Bispecific Antibody Can be Safely Combined with the T-Cell-Engaging Bispecific Antibody Glofitamab in Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma","year":2022,"lang":"en","type":"article","venue":"Blood","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Roche (Canada)","funders":"","keywords":"Cytokine release syndrome; Medicine; Lymphoma; T cell; Pharmacology; CD8; Antibody; Immune system; Immunology; Cancer research; Chimeric antigen receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003840288,0.0003878732,0.001033413,0.0002571641,0.0001362657,0.0003787982,0.0004243394,0.0004138857,0.001445697],"category_scores_gemma":[0.0002058344,0.0001915136,0.0003627935,0.0002129454,0.0003098672,0.0003295376,0.0002390677,0.001047664,0.0004835618],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003896527,"about_ca_system_score_gemma":0.0003945243,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004498981,"about_ca_topic_score_gemma":0.001191661,"domain_scores_codex":[0.999809,0.00006794385,0.00001284107,0.00002620916,0.00002756818,0.00005649],"domain_scores_gemma":[0.9998811,0.00001802947,0.00003133177,0.00001351257,0.000006511225,0.00004933821],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.04200581,0.01100401,0.004410942,0.0005939517,0.0003324654,0.0008382007,0.0002181582,0.002708677,0.8242281,0.0003012958,0.002144023,0.1112143],"study_design_scores_gemma":[0.05178872,0.4807155,0.03432516,0.00005974829,0.0007770916,0.004238841,0.0001684006,0.005148684,0.4050582,0.0002859361,0.01737071,0.00006299666],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971455,0.001142237,0.0004805809,0.00008166685,0.0000156428,0.0001934058,0.0002201051,0.00008183228,0.000638958],"genre_scores_gemma":[0.9977035,0.0005087673,0.0006044541,0.00007521125,0.00002132712,0.0001218402,0.0004146687,0.00001280905,0.0005374704],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001445697,"threshold_uncertainty_score":0.00483638,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02550848359045453,"score_gpt":0.2883838006253497,"score_spread":0.2628753170348951,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}