{"id":"W4310096327","doi":"10.1182/blood-2022-169920","title":"IMiDs Synergize with EP300 Inhibition to Disrupt the Ikzf/MYC/IRF4 Axis in Multiple Myeloma","year":2022,"lang":"en","type":"article","venue":"Blood","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research; University of Calgary","funders":"","keywords":"Cancer research; Multiple myeloma; Downregulation and upregulation; IRF4; Biology; Transcription factor; Coactivator; Pomalidomide; Lenalidomide; Immunology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001226693,0.0004639399,0.0004606525,0.0003502487,0.0001190688,0.0002375091,0.0003489341,0.0002532025,0.00165869],"category_scores_gemma":[0.00007719843,0.00009558786,0.000251576,0.0002360631,0.0002044478,0.0002081139,0.0001955982,0.0008232213,0.0003894004],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000314162,"about_ca_system_score_gemma":0.0002275932,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003890113,"about_ca_topic_score_gemma":0.001176312,"domain_scores_codex":[0.9999157,0.00001338157,0.000006582226,0.00001211298,0.00002548645,0.0000267682],"domain_scores_gemma":[0.9999679,0.000005454135,0.000006908178,0.000004505348,0.000002663965,0.00001259586],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002987587,0.001291479,0.0004361322,0.0002299477,0.00006370831,0.0001827408,0.00003380058,0.001099687,0.9558517,0.0005437867,0.0009376028,0.03634183],"study_design_scores_gemma":[0.0006385685,0.006414216,0.005061334,0.00001093389,0.00009663042,0.0004762962,0.00002740101,0.002407306,0.9750478,0.0002004336,0.009605866,0.0000132112],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9879575,0.003853128,0.001856264,0.000277653,0.0001113467,0.0001414884,0.0005207239,0.0002455828,0.005036358],"genre_scores_gemma":[0.9924429,0.002141289,0.001620343,0.00009813688,0.00003643212,0.0000726178,0.0005178213,0.00002074136,0.003049694],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00165869,"threshold_uncertainty_score":0.005548835,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01876321567820754,"score_gpt":0.2670754296227389,"score_spread":0.2483122139445313,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}