{"id":"W4310096555","doi":"10.1182/blood-2022-167804","title":"High Metabolic Tumor Volume Is Associated with Higher Toxicity and Decreased Efficacy of BCMA CAR-T Cell Therapy in Multiple Myeloma","year":2022,"lang":"en","type":"article","venue":"Blood","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Medicine; Multiple myeloma; Bone marrow; Chimeric antigen receptor; Internal medicine; Oncology; Lenalidomide; Cohort; Chemotherapy; Cancer; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003281053,0.0001673699,0.0003009028,0.0006674366,0.0002164217,0.0004302853,0.0001774743,0.0001631684,0.0009446343],"category_scores_gemma":[0.0009177414,0.0001085254,0.0002159367,0.000763089,0.0001684191,0.0002235246,0.0003051024,0.0002049684,0.0001246648],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002910447,"about_ca_system_score_gemma":0.0001462522,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006158084,"about_ca_topic_score_gemma":0.0008584723,"domain_scores_codex":[0.999769,0.00004635022,0.00002710622,0.00004433736,0.0000817398,0.00003150626],"domain_scores_gemma":[0.9994056,0.00009311113,0.0003625765,0.00003041055,0.00004039557,0.00006792902],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005303403,0.00002507906,0.9850112,0.00001897206,0.00003723777,0.0003086397,0.00003373289,0.000281952,0.006235568,0.00003278124,0.00008504616,0.007399661],"study_design_scores_gemma":[0.000006101374,0.0001796477,0.9963509,0.000002654906,0.0000265905,0.001524796,0.00003146827,0.0004704617,0.001094256,0.00004087268,0.0002694458,0.000002808652],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988237,0.0003888084,0.0002328781,0.00001659836,0.000001539263,0.000006325275,0.0001637826,0.000008975208,0.0003574653],"genre_scores_gemma":[0.9994828,0.00007394701,0.0001763657,0.000006967123,0.000004398784,0.000006709494,0.0001789349,0.000003995258,0.00006585833],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009446343,"threshold_uncertainty_score":0.003160179,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01869291281631465,"score_gpt":0.2527591697439556,"score_spread":0.2340662569276409,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}