{"id":"W4310099962","doi":"10.1016/j.jaci.2022.10.022","title":"The diagnosis of severe combined immunodeficiency (SCID): The Primary Immune Deficiency Treatment Consortium (PIDTC) 2022 Definitions","year":2022,"lang":"en","type":"article","venue":"Journal of Allergy and Clinical Immunology","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":125,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; CancerCare Manitoba; University of Calgary; Université de Montréal; University of Manitoba; Centre Hospitalier Universitaire Sainte-Justine","funders":"NHLBI Division of Intramural Research; National Institute of Neurological Disorders and Stroke; National Institute of Allergy and Infectious Diseases; National Heart, Lung, and Blood Institute; Office of Naval Research; National Center for Advancing Translational Sciences; Health Resources and Services Administration; St. Baldrick's Foundation; CSL Behring; California Institute of Regenerative Medicine; Invitae; National Cancer Institute; U.S. Department of Health and Human Services; National Institutes of Health; Grifols","keywords":"Severe combined immunodeficiency; Primary immunodeficiency; Immunology; Immune system; T cell; Hepatosplenomegaly; Medicine; Immunodeficiency; Stem cell; Genetic enhancement; Biology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002714951,0.001286918,0.0008728241,0.003649285,0.001245971,0.001199125,0.001623319,0.001314274,0.005630601],"category_scores_gemma":[0.004960548,0.0001927618,0.001017763,0.003099178,0.001895972,0.0009048561,0.002281095,0.002067148,0.001499876],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00165425,"about_ca_system_score_gemma":0.00433608,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007487307,"about_ca_topic_score_gemma":0.005143838,"domain_scores_codex":[0.997101,0.0008841869,0.0006657385,0.0002835588,0.0006951297,0.0003703252],"domain_scores_gemma":[0.9963084,0.0005412929,0.0007755391,0.0001396686,0.001619555,0.0006155725],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001086959,0.0003211113,0.1255619,0.00257144,0.0002448087,0.01013975,0.001321635,0.001701734,0.004368938,0.06449732,0.4504414,0.337743],"study_design_scores_gemma":[0.0001496024,0.0003962246,0.0664711,0.003627317,0.000185356,0.05765684,0.0008258155,0.002150539,0.0017331,0.015054,0.8516192,0.0001308759],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"other","genre_gemma":"methods","genre_scores_codex":[0.1536274,0.2581635,0.09682837,0.05971742,0.01785681,0.005041596,0.03401864,0.001175502,0.3735707],"genre_scores_gemma":[0.6383769,0.08819459,0.1157907,0.0289558,0.01121179,0.005545435,0.08129191,0.0003656779,0.03026718],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.007487307,"threshold_uncertainty_score":0.01883626,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02430651909327762,"score_gpt":0.2680864373464738,"score_spread":0.2437799182531962,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}