{"id":"W4310099962","doi":"10.1016/j.jaci.2022.10.022","title":"The diagnosis of severe combined immunodeficiency (SCID): The Primary Immune Deficiency Treatment Consortium (PIDTC) 2022 Definitions","year":2022,"lang":"en","type":"article","venue":"Journal of Allergy and Clinical Immunology","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":125,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; CancerCare Manitoba; University of Calgary; Université de Montréal; University of Manitoba; Centre Hospitalier Universitaire Sainte-Justine","funders":"NHLBI Division of Intramural Research; National Institute of Neurological Disorders and Stroke; National Institute of Allergy and Infectious Diseases; National Heart, Lung, and Blood Institute; Office of Naval Research; National Center for Advancing Translational Sciences; Health Resources and Services Administration; St. Baldrick's Foundation; CSL Behring; California Institute of Regenerative Medicine; Invitae; National Cancer Institute; U.S. Department of Health and Human Services; National Institutes of Health; Grifols","keywords":"Severe combined immunodeficiency; Primary immunodeficiency; Immunology; Immune system; T cell; Hepatosplenomegaly; Medicine; Immunodeficiency; Stem cell; Genetic enhancement; Biology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["sts"],"consensus_categories":["sts"],"category_scores_codex":[0.002590721,0.0003484964,0.0009849082,0.0001691405,0.002887922,0.00003383767,0.001358004,0.0002669294,0.0007488221],"category_scores_gemma":[0.0005226525,0.0002081889,0.0008101802,0.0004644874,0.00287162,0.0001393074,0.0006346482,0.001563118,0.00002580907],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001182359,"about_ca_system_score_gemma":0.0005451025,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001572282,"about_ca_topic_score_gemma":0.00001858542,"domain_scores_codex":[0.9943568,0.00195067,0.002532215,0.0003411927,0.0001678066,0.0006512838],"domain_scores_gemma":[0.9932668,0.003792536,0.001875172,0.0007670477,0.0002799701,0.00001843808],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.02569654,0.03221794,0.02644088,0.000074852,0.02837254,0.0001676219,0.0105158,0.001534387,0.08913378,0.1498759,0.005066955,0.6309028],"study_design_scores_gemma":[0.02134028,0.02605834,0.3608449,0.0001060091,0.001229612,0.003489315,0.02919968,0.0000178013,0.002474873,0.01123986,0.5429043,0.001094916],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6999121,0.2924782,0.00002171142,0.00285729,0.003056735,0.0002873824,0.00004271646,0.00001957382,0.00132424],"genre_scores_gemma":[0.9181684,0.08050852,0.00001557449,0.0003116047,0.0000113918,0.00008331972,0.00003699052,0.00002364316,0.0008405816],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6298078,"threshold_uncertainty_score":0.999842,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02430651909327762,"score_gpt":0.2680864373464738,"score_spread":0.2437799182531962,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}