{"id":"W4310104769","doi":"10.1182/blood-2022-169605","title":"Itacitinib and Corticosteroids As Initial Treatment for Chronic Graft-Versus-Host Disease: Phase 1/2 Results from Gravitas-309","year":2022,"lang":"en","type":"article","venue":"Blood","topic":"Hematopoietic Stem Cell Transplantation","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Medicine; Internal medicine; Gastroenterology; Methylprednisolone; Cohort; Prednisone; Graft-versus-host disease; Tacrolimus; Transplantation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002742952,0.00133653,0.002019578,0.0004562602,0.0004530194,0.001184324,0.0006890577,0.001241204,0.003492017],"category_scores_gemma":[0.001231083,0.0003973013,0.001882697,0.0004516088,0.0008169253,0.0009728423,0.0003641166,0.003919821,0.0008068748],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001256174,"about_ca_system_score_gemma":0.0018714,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000877901,"about_ca_topic_score_gemma":0.003131657,"domain_scores_codex":[0.9993263,0.0002895449,0.00003698434,0.00009680325,0.00009082063,0.0001595795],"domain_scores_gemma":[0.9990088,0.0002070065,0.0001710933,0.00007548942,0.00008963265,0.0004479142],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6784662,0.0861906,0.005015077,0.001648008,0.002484254,0.0004559965,0.0003711247,0.003571094,0.02819792,0.0006223927,0.01304629,0.1799311],"study_design_scores_gemma":[0.6063531,0.3690964,0.0102188,0.0001771434,0.001173662,0.0006051846,0.00007956189,0.001334782,0.003914743,0.0004646944,0.006519183,0.00006279928],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9753755,0.01209232,0.0009444646,0.001515836,0.0003378807,0.003477241,0.001946606,0.0001267826,0.004183455],"genre_scores_gemma":[0.9735863,0.007774455,0.002918796,0.00352806,0.0005209747,0.003190143,0.005150965,0.00006895034,0.003261329],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003492017,"threshold_uncertainty_score":0.01450628,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04047826888902684,"score_gpt":0.3365661468789158,"score_spread":0.2960878779898889,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}