{"id":"W4310104796","doi":"10.1182/blood-2022-158370","title":"Preliminary Results from a Phase 2 Open-Label, Multicenter, Dose Optimization Clinical Study of the Safety, Tolerability, and Pharmacokinetic (PK) and Pharmacodynamic (PD) Profiles of Cfi-400945 As a Single Agent or in Combination with Azacitidine or Decitabine in Patients with Acute Myeloid Leukemia, Myelodysplastic Syndrome or Chronic Myelomonocytic Leukemia (TWT-202)","year":2022,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Pharmacokinetics; Tolerability; Pharmacodynamics; Pharmacology; Medicine; Clinical trial; Phases of clinical research; Adverse effect; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002334518,0.001570639,0.001633612,0.0003783168,0.0004807942,0.0009977211,0.0009904673,0.001284208,0.003348116],"category_scores_gemma":[0.001836366,0.000534487,0.001058884,0.0005417858,0.0008038798,0.00094902,0.0002834141,0.003726183,0.00068855],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00111576,"about_ca_system_score_gemma":0.001457374,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001176631,"about_ca_topic_score_gemma":0.002838359,"domain_scores_codex":[0.9993126,0.0003311252,0.00003739604,0.0001166372,0.00008985423,0.000112342],"domain_scores_gemma":[0.9989321,0.0003172904,0.0002211388,0.0001246665,0.00009314364,0.0003116803],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.3806819,0.1073616,0.009642893,0.000906494,0.001700188,0.0006556749,0.0009507621,0.01026504,0.2558338,0.0005181787,0.008935525,0.222548],"study_design_scores_gemma":[0.2140839,0.7072423,0.03503048,0.000044453,0.0007834167,0.00100245,0.0001190696,0.003714445,0.02999554,0.0004636264,0.007439672,0.00008068667],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9868156,0.001833865,0.002815796,0.0005794015,0.00006710283,0.003074476,0.002314395,0.000225303,0.00227407],"genre_scores_gemma":[0.9796664,0.001232695,0.007336123,0.0009185484,0.0001183669,0.002651367,0.005583075,0.00009347773,0.002399922],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003348116,"threshold_uncertainty_score":0.01234627,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03387899499718823,"score_gpt":0.3366869457545766,"score_spread":0.3028079507573884,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}