{"id":"W4310105226","doi":"10.1182/blood-2022-163257","title":"Initiating First-Line (1L) Ibrutinib (Ibr) in Patients (pts) with Chronic Lymphocytic Leukemia (CLL) Improves Overall Survival (OS) Outcomes to Rates Approximating an Age-Matched Population of ≥65 Years","year":2022,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; Alberta Health Services","funders":"","keywords":"Medicine; Chemoimmunotherapy; Ibrutinib; Population; Fludarabine; Internal medicine; Oncology; Hazard ratio; Clinical trial; Venetoclax; Chronic lymphocytic leukemia; Chemotherapy; Leukemia; Confidence interval; Cyclophosphamide","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00324495,0.0003908702,0.001048537,0.0005708193,0.0002233067,0.0007895469,0.0004170245,0.0004247603,0.002152987],"category_scores_gemma":[0.003345701,0.0001778465,0.00105598,0.0007470524,0.0002768808,0.0005035434,0.000505141,0.0006584979,0.0003430005],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007256801,"about_ca_system_score_gemma":0.0007130339,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005978408,"about_ca_topic_score_gemma":0.002032698,"domain_scores_codex":[0.9990067,0.00043725,0.00006982242,0.0002394166,0.0001465733,0.0001003295],"domain_scores_gemma":[0.998574,0.0004018469,0.0007125737,0.00008125915,0.00009596727,0.0001344078],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.2038357,0.003322407,0.3289776,0.004254221,0.01172294,0.0001854463,0.0003511195,0.005824765,0.01626871,0.0002634362,0.008140035,0.4168537],"study_design_scores_gemma":[0.03555303,0.09937378,0.8142835,0.0007908893,0.01804725,0.001006786,0.0002388355,0.002857364,0.009003524,0.0005789043,0.01819268,0.00007344106],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9750231,0.01725945,0.0008456492,0.0004052467,0.00006810828,0.0004329224,0.003859773,0.0001000747,0.002005671],"genre_scores_gemma":[0.9881505,0.004009886,0.000767022,0.0007118544,0.000139573,0.0003771379,0.005049951,0.00002183263,0.0007722752],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00324495,"threshold_uncertainty_score":0.01716113,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02164568093588366,"score_gpt":0.289335104284127,"score_spread":0.2676894233482433,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}