{"id":"W4310105226","doi":"10.1182/blood-2022-163257","title":"Initiating First-Line (1L) Ibrutinib (Ibr) in Patients (pts) with Chronic Lymphocytic Leukemia (CLL) Improves Overall Survival (OS) Outcomes to Rates Approximating an Age-Matched Population of ≥65 Years","year":2022,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; Alberta Health Services","funders":"","keywords":"Medicine; Chemoimmunotherapy; Ibrutinib; Population; Fludarabine; Internal medicine; Oncology; Hazard ratio; Clinical trial; Venetoclax; Chronic lymphocytic leukemia; Chemotherapy; Leukemia; Confidence interval; Cyclophosphamide","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000830552,0.0003394847,0.0008602488,0.0003963096,0.0001708848,0.00004815549,0.0003409805,0.0001089913,0.00009928618],"category_scores_gemma":[0.0005972518,0.0003156721,0.0001098774,0.0007437618,0.00006966849,0.0002448235,0.000424757,0.0003876133,0.000009613027],"about_ca_system_candidate":true,"about_ca_system_consensus":true,"about_ca_system_score_codex":0.02634311,"about_ca_system_score_gemma":0.006302563,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01007916,"about_ca_topic_score_gemma":0.001315411,"domain_scores_codex":[0.9962041,0.0002129939,0.0009579659,0.0006475527,0.001245114,0.0007322768],"domain_scores_gemma":[0.9982413,0.0003327538,0.0003739188,0.0006827503,0.0001307331,0.0002385279],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002690923,0.002654679,0.9326033,0.002229981,0.0006164483,0.0005305423,0.007240507,0.03702621,0.005436621,0.0001825069,0.0000346863,0.00875357],"study_design_scores_gemma":[0.1182353,0.004139108,0.8157589,0.0004914051,0.0002341173,0.00005352168,0.0006999576,0.05688544,0.002698531,0.0001190867,0.0000362093,0.0006484643],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979651,0.00006804936,0.0000190525,0.0000403804,0.0001136239,0.001460881,0.00003936248,0.0001009256,0.0001926187],"genre_scores_gemma":[0.9972529,0.000006551345,0.001687955,0.0001254614,0.0001096725,0.0001968894,0.0004159266,0.000100428,0.0001042137],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1168444,"threshold_uncertainty_score":0.9999295,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02164568093588366,"score_gpt":0.289335104284127,"score_spread":0.2676894233482433,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}