{"id":"W4310106485","doi":"10.1182/blood-2022-170366","title":"Metformin Treatment Abrogates the Competitive Advantage of <i>Dnmt3a</i> R878H HSPCs By Enhancing DNA Methylation Activity","year":2022,"lang":"en","type":"article","venue":"Blood","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Occupational Cancer Research Centre; Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Biology; Haematopoiesis; Progenitor cell; DNA methylation; Gene knockdown; Metformin; Methylation; Cancer research; Stem cell; Molecular biology; Cell biology; DNA; Genetics; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000174,0.0002998521,0.000481624,0.0002003058,0.0001728444,0.0002593026,0.0003430085,0.0003395684,0.002468177],"category_scores_gemma":[0.0001643463,0.0001488446,0.0003532516,0.0001540517,0.000218672,0.0001718029,0.0002371283,0.001242975,0.00047229],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002640611,"about_ca_system_score_gemma":0.0003832657,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001516102,"about_ca_topic_score_gemma":0.002936514,"domain_scores_codex":[0.9997451,0.00003639704,0.00003465606,0.00003803066,0.00006117622,0.0000846829],"domain_scores_gemma":[0.9998339,0.0000297375,0.00003503012,0.00001775047,0.00001746891,0.0000660046],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001032679,0.0003899097,0.0005093824,0.0001088173,0.00002944765,0.00009523503,0.0000433525,0.0002439873,0.9918323,0.0002310814,0.0005242262,0.004959621],"study_design_scores_gemma":[0.0001246697,0.002604388,0.008944377,0.00001474015,0.00005305596,0.0002220829,0.0000856138,0.001916699,0.9794306,0.00008003673,0.006509311,0.00001437326],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994259,0.001384825,0.001056654,0.0002346245,0.0001169425,0.00005812017,0.0008578402,0.0001836502,0.001848226],"genre_scores_gemma":[0.9944265,0.000836471,0.001015097,0.0001310284,0.00002009497,0.000100019,0.0008760713,0.00002726311,0.002567464],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002468177,"threshold_uncertainty_score":0.008256853,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006986251023224363,"score_gpt":0.2443040589881549,"score_spread":0.2373178079649305,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}