{"id":"W4310109630","doi":"10.1182/blood-2022-165887","title":"Alberta Cellular and Immunotherapy (ACIT) 001, Results of Decentralized Production of Second Generation, Anti-CD19/41BB/CD3z Chimeric Antigen Receptor (CAR) T-Cells in Relapsed/Refractory (R/R) Acute Lymphoblastic Leukemia (ALL) and Aggressive Non-Hodgkin Lymphoma (NHL)","year":2022,"lang":"en","type":"article","venue":"Blood","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Stollery Children's Hospital; Alberta Children's Hospital; University of Alberta; University of Calgary","funders":"","keywords":"Medicine; Fludarabine; Chimeric antigen receptor; Blinatumomab; Internal medicine; Immunotherapy; Oncology; Cyclophosphamide; Clinical trial; CD19; Immunology; Antigen; Chemotherapy; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001277708,0.0006530281,0.000339105,0.0005026461,0.0004955834,0.0008170891,0.0006826892,0.000619327,0.002762908],"category_scores_gemma":[0.000457694,0.0001961138,0.0003717446,0.0003118178,0.0005915031,0.0001769774,0.0004254825,0.001149243,0.0005467273],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002681799,"about_ca_system_score_gemma":0.004965097,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02739686,"about_ca_topic_score_gemma":0.06391536,"domain_scores_codex":[0.9994721,0.0001421986,0.00001279299,0.00008836575,0.0001960964,0.00008849579],"domain_scores_gemma":[0.9995289,0.00004192976,0.00006989783,0.00004697223,0.00008495341,0.0002273454],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.03340642,0.01812532,0.0164218,0.0009204822,0.0003557758,0.001337046,0.0003921866,0.01088083,0.4937404,0.006265376,0.05633401,0.3618205],"study_design_scores_gemma":[0.05292169,0.2088808,0.1179139,0.0001724982,0.0008501332,0.003164192,0.0001854064,0.008428433,0.3182614,0.001603319,0.2875241,0.0000940451],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8998974,0.01036766,0.01232785,0.002142101,0.0005211607,0.008445493,0.008559596,0.0009019494,0.05683684],"genre_scores_gemma":[0.9396886,0.004078003,0.01301915,0.001176905,0.0002635768,0.001960346,0.01346216,0.0000976853,0.02625353],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02739686,"threshold_uncertainty_score":0.05447477,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01078200934270225,"score_gpt":0.245702864044933,"score_spread":0.2349208547022308,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}