{"id":"W4310112891","doi":"10.1182/blood-2022-167696","title":"Pediatric Sickle Cell Disease: A Potential Role for the Complement System","year":2022,"lang":"en","type":"article","venue":"Blood","topic":"Hemoglobinopathies and Related Disorders","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; University Health Network; Hospital for Sick Children; University of Toronto","funders":"","keywords":"Medicine; Acute chest syndrome; Complement system; Disease; Eculizumab; Sickle cell anemia; Vaso-occlusive crisis; Immune system; Organ dysfunction; Internal medicine; Immunology; Pediatrics; Sepsis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003194541,0.0002305938,0.0002061819,0.0003029026,0.0002978355,0.000502585,0.0001676134,0.0002100515,0.001739101],"category_scores_gemma":[0.0004302771,0.00006049181,0.0001225052,0.000401926,0.0003227453,0.0002051743,0.0002091045,0.0002945657,0.0001006967],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007300026,"about_ca_system_score_gemma":0.001069051,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004859469,"about_ca_topic_score_gemma":0.006665783,"domain_scores_codex":[0.9998204,0.00005789248,0.00001518576,0.0000207185,0.00003912425,0.00004674659],"domain_scores_gemma":[0.9996717,0.0000809344,0.000120939,0.000006544546,0.00005667796,0.00006321129],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0007146104,0.0001136338,0.9556324,0.0004306877,0.00005085571,0.005403049,0.0004936637,0.000163536,0.0072542,0.001494269,0.001738835,0.02651031],"study_design_scores_gemma":[0.00004139113,0.001018277,0.9610751,0.0003340868,0.0001125631,0.01736894,0.0009998564,0.0004099763,0.002100575,0.0005295019,0.01599805,0.00001177886],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9689348,0.02533074,0.0004279819,0.001057787,0.00004218333,0.00005729524,0.0003377714,0.00001006467,0.003801429],"genre_scores_gemma":[0.9937345,0.00502622,0.0005341405,0.0001265213,0.00005301655,0.00001895006,0.0001404542,0.000001279332,0.0003647534],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004859469,"threshold_uncertainty_score":0.00966239,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005762012056404568,"score_gpt":0.2076402935617938,"score_spread":0.2018782815053892,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}