{"id":"W4310117676","doi":"10.1182/blood-2022-166809","title":"A First-in-Human Phase 1 Study of Abbv-319, an Antibody-Drug Conjugate Composed of a CD19 Antibody Linked to a Potent Proprietary Glucocorticoid Receptor Modulator, in Patients with Relapsed or Refractory B-Cell Malignancies","year":2022,"lang":"en","type":"article","venue":"Blood","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Antibody; Follicular lymphoma; Chronic lymphocytic leukemia; B cell; Internal medicine; Antibody-drug conjugate; Lymphoma; Oncology; Cancer research; Immunology; Pharmacology; Leukemia; Monoclonal antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001165935,0.001556862,0.001636579,0.0003717907,0.0004996277,0.000936078,0.0008137632,0.001272226,0.003325196],"category_scores_gemma":[0.0005645203,0.000570835,0.0009745484,0.0002838219,0.0007658945,0.0009260693,0.0003019051,0.002771433,0.0009781278],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001033705,"about_ca_system_score_gemma":0.00148424,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008422779,"about_ca_topic_score_gemma":0.002524125,"domain_scores_codex":[0.9996554,0.000114147,0.00001462503,0.0000846188,0.00003585313,0.00009528956],"domain_scores_gemma":[0.9995621,0.00005187618,0.00007516562,0.0000376567,0.00004083365,0.0002323654],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.2550825,0.2208963,0.01223097,0.001661038,0.001560166,0.001049738,0.0009041912,0.007298726,0.2792544,0.0009048317,0.01568188,0.2034753],"study_design_scores_gemma":[0.1533487,0.7993149,0.01298068,0.00003856323,0.0004211679,0.000943748,0.0001057374,0.001874254,0.01953645,0.0004226915,0.01096366,0.00004949455],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9849623,0.00256506,0.001623677,0.0004823121,0.0001407827,0.004960467,0.002444406,0.000200043,0.002620858],"genre_scores_gemma":[0.9799814,0.001992068,0.003619618,0.001213862,0.0001501401,0.003919314,0.003907956,0.00008073584,0.005134903],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003325196,"threshold_uncertainty_score":0.0111239,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01815749915306182,"score_gpt":0.3073109476616785,"score_spread":0.2891534485086167,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}