{"id":"W4310119420","doi":"10.1182/blood-2022-159389","title":"Improvement in Individual Symptoms and Total Symptom Score (TSS) and Matching-Adjusted Indirect Comparison (MAIC) Analysis to Compare TSS As a Continuous Endpoint in Patients with Myelofibrosis Treated with Pelabresib in Combination with Ruxolitinib Versus Janus Kinase Inhibitor Monotherapy","year":2022,"lang":"en","type":"article","venue":"Blood","topic":"Myeloproliferative Neoplasms: Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"","keywords":"Medicine; Clinical endpoint; Ruxolitinib; Internal medicine; Clinical trial; Phases of clinical research; Myelofibrosis; Surrogate endpoint; Surgery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00768472,0.001121866,0.002419953,0.000782963,0.0002887584,0.0007874329,0.0008775494,0.0007320609,0.006728468],"category_scores_gemma":[0.01029044,0.0002037768,0.005304742,0.0006173759,0.0005259863,0.000848044,0.0009526006,0.002154459,0.0002695603],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005789751,"about_ca_system_score_gemma":0.0005831009,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005907766,"about_ca_topic_score_gemma":0.001011796,"domain_scores_codex":[0.9932944,0.004431509,0.0004399726,0.0009828223,0.000564404,0.0002867066],"domain_scores_gemma":[0.9925863,0.005013245,0.001180935,0.0005869546,0.0002817854,0.0003508764],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.7781392,0.002372107,0.08628617,0.002694386,0.07438133,0.0001465836,0.0002095157,0.003436204,0.004678125,0.001140155,0.003607066,0.04290912],"study_design_scores_gemma":[0.09038427,0.1988465,0.5697662,0.0005472267,0.06469885,0.0005965529,0.0006533843,0.04869215,0.009872086,0.005154079,0.0104944,0.0002942735],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9828531,0.004152729,0.004563935,0.0003718792,0.0005706037,0.0008288287,0.004322654,0.0001070082,0.002229179],"genre_scores_gemma":[0.9907405,0.0002925029,0.003831969,0.0002178541,0.0001108968,0.001746617,0.001852169,0.0000282147,0.001179163],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00768472,"threshold_uncertainty_score":0.04064119,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01181178246426865,"score_gpt":0.2388237261623891,"score_spread":0.2270119436981205,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}