{"id":"W4310120142","doi":"10.1182/blood-2022-157691","title":"Mosunetuzumab Monotherapy Demonstrates Durable Efficacy with a Manageable Safety Profile in Patients with Relapsed/Refractory Follicular Lymphoma Who Received ≥2 Prior Therapies: Updated Results from a Pivotal Phase II Study","year":2022,"lang":"en","type":"article","venue":"Blood","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Roche (Canada); Princess Margaret Cancer Centre; Jewish General Hospital; McGill University; Spinal Cord Injury BC; University of British Columbia","funders":"","keywords":"Follicular lymphoma; Medicine; Refractory (planetary science); Safety profile; Oncology; Internal medicine; Rituximab; Lymphoma; Phases of clinical research; Follicular phase; Clinical trial; Adverse effect","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001094259,0.0004349343,0.001009308,0.0001744863,0.0001714062,0.0007061976,0.0003049041,0.0002830032,0.001121135],"category_scores_gemma":[0.0006846315,0.0001804864,0.0006547799,0.0003018274,0.000209962,0.0003493662,0.0001489235,0.0008508,0.0003090901],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006239717,"about_ca_system_score_gemma":0.0004387627,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005435616,"about_ca_topic_score_gemma":0.001941195,"domain_scores_codex":[0.9997573,0.00008034324,0.00002288893,0.00004118468,0.00004575973,0.00005253319],"domain_scores_gemma":[0.9995541,0.00009794339,0.0001536572,0.00003463457,0.0000481488,0.0001114984],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.1916475,0.009031726,0.1149242,0.001708135,0.003770558,0.0008496923,0.0005430676,0.003136301,0.1052113,0.0002535983,0.01207396,0.5568501],"study_design_scores_gemma":[0.1262793,0.282896,0.5106041,0.0003647308,0.005785786,0.004907936,0.0003178779,0.005755082,0.02120166,0.0004381238,0.04133948,0.0001099524],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9902142,0.006946214,0.0002954181,0.0002009685,0.00002886038,0.0002346271,0.0005214552,0.0000379466,0.001520288],"genre_scores_gemma":[0.9951858,0.002286508,0.0003965249,0.0003017547,0.00005238571,0.0001613826,0.001185762,0.000009641875,0.0004202221],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001121135,"threshold_uncertainty_score":0.005787015,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01069748530457965,"score_gpt":0.2509131653512022,"score_spread":0.2402156800466226,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}