{"id":"W4310125603","doi":"10.1182/blood-2022-168228","title":"The Prognostic Impact of <i>HMGCLL1</i> Gene Variant on Treatment Outcomes in Chronic Myeloid Leukemia (CML) Patients: Adverse Impact on the Response, Failure, and Progression with Imatinib Which Can be Abrogated By the Use of 2nd Generation Tyrosine Kinase Inhibitor (TKI) Upfront Therapy","year":2022,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Ontario Institute for Cancer Research; University of Toronto; University Health Network","funders":"","keywords":"Imatinib; Myeloid leukemia; Medicine; Adverse effect; Internal medicine; Oncology; Imatinib mesylate; Immunology; Cancer research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000196233,0.0001652135,0.0002722426,0.0003572074,0.0002618224,0.0002748139,0.0001489967,0.0003013096,0.001247657],"category_scores_gemma":[0.0005966409,0.00008943074,0.0001879277,0.0003472561,0.000232022,0.0001580964,0.0002256084,0.0002327958,0.0002043558],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001784691,"about_ca_system_score_gemma":0.0001358736,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007123992,"about_ca_topic_score_gemma":0.0007363401,"domain_scores_codex":[0.9998677,0.00002913298,0.00001399856,0.00004001478,0.00002026486,0.00002893021],"domain_scores_gemma":[0.9997277,0.00005405174,0.0001066517,0.00001864618,0.00001993153,0.00007300921],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001546058,0.00004830962,0.993369,0.00001022631,0.00002665047,0.0002924174,0.00004079453,0.00005509476,0.002157212,0.00001692095,0.00007884159,0.002358496],"study_design_scores_gemma":[0.00004524702,0.0005009093,0.9971787,0.000004366817,0.00003806059,0.0009933572,0.00007507283,0.0002836501,0.0004673782,0.00003881889,0.0003708276,0.000003476109],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996481,0.00007622143,0.0000348341,0.000008983739,0.000001982545,0.000004604519,0.0001210631,7.831113e-7,0.0001034794],"genre_scores_gemma":[0.999521,0.00003256232,0.00004005726,0.00001298352,0.00001017108,0.000008008639,0.0002814245,7.879828e-7,0.00009307935],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001247657,"threshold_uncertainty_score":0.004173815,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02146055768878582,"score_gpt":0.2737014019438256,"score_spread":0.2522408442550398,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}