{"id":"W4310126655","doi":"10.1182/blood-2022-158180","title":"Iberdomide (IBER) in Combination with Dexamethasone (DEX) in Relapsed/Refractory Multiple Myeloma (RRMM): Results from the Anti-B-Cell Maturation Antigen (BCMA)-Exposed Cohort of the CC-220-MM-001 Trial","year":2022,"lang":"en","type":"article","venue":"Blood","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen Elizabeth II Health Sciences Centre; Dalhousie University","funders":"","keywords":"Multiple myeloma; Medicine; Dexamethasone; Lenalidomide; Internal medicine; Refractory (planetary science); Oncology; Immunology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001360132,0.0005295153,0.000998023,0.0002589157,0.0002058064,0.000879437,0.0003858824,0.0004229578,0.001618373],"category_scores_gemma":[0.0006928876,0.0001939992,0.001033734,0.0004415353,0.0003094395,0.0004276922,0.0002817739,0.00129739,0.000363143],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000770517,"about_ca_system_score_gemma":0.0006441142,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001034987,"about_ca_topic_score_gemma":0.003337102,"domain_scores_codex":[0.9995223,0.0002230449,0.00004354799,0.00007993493,0.0000595382,0.00007161898],"domain_scores_gemma":[0.9995383,0.00007364511,0.0001447019,0.00003567669,0.00002546976,0.0001822972],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5969055,0.0158181,0.04085069,0.001497888,0.00391664,0.0004049639,0.0004098748,0.002963824,0.03266606,0.0003472922,0.007379584,0.2968397],"study_design_scores_gemma":[0.3857928,0.392932,0.182751,0.0003878298,0.005664631,0.001939255,0.0003235218,0.001846211,0.009647781,0.0004998459,0.01813272,0.00008228672],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9850067,0.00990994,0.0002859236,0.0005171846,0.00007287224,0.0005778895,0.001446067,0.00004346108,0.002139853],"genre_scores_gemma":[0.9892341,0.004867041,0.0008504955,0.0007497781,0.0001369225,0.000408818,0.002621559,0.00001593249,0.001115324],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001618373,"threshold_uncertainty_score":0.007193148,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008596450704891333,"score_gpt":0.2031214575849355,"score_spread":0.1945250068800441,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}