{"id":"W4310126655","doi":"10.1182/blood-2022-158180","title":"Iberdomide (IBER) in Combination with Dexamethasone (DEX) in Relapsed/Refractory Multiple Myeloma (RRMM): Results from the Anti-B-Cell Maturation Antigen (BCMA)-Exposed Cohort of the CC-220-MM-001 Trial","year":2022,"lang":"en","type":"article","venue":"Blood","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen Elizabeth II Health Sciences Centre; Dalhousie University","funders":"","keywords":"Multiple myeloma; Medicine; Dexamethasone; Lenalidomide; Internal medicine; Refractory (planetary science); Oncology; Immunology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007075523,0.0001587246,0.0002009881,0.000059437,0.0001382576,0.00002043313,0.000334356,0.0001255593,0.0000135535],"category_scores_gemma":[0.0003401679,0.0001111869,0.00007101462,0.0003094758,0.00008292432,0.00001146746,0.0001977967,0.0002851418,0.000001787588],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004054037,"about_ca_system_score_gemma":0.00018163,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00055323,"about_ca_topic_score_gemma":0.0006548199,"domain_scores_codex":[0.9980683,0.0005512939,0.0004911348,0.0003728879,0.0003341619,0.000182227],"domain_scores_gemma":[0.9988823,0.0001293651,0.0003652195,0.0005328229,0.000061755,0.00002853153],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01684181,0.008175074,0.06853269,0.00001182659,0.00009609264,0.000009136217,0.000719819,0.0002158643,0.9030846,0.00002216517,0.001185053,0.00110591],"study_design_scores_gemma":[0.1715704,0.0007751429,0.1296724,0.00002969721,0.00003813055,0.000004116825,0.0003027137,0.0001788687,0.6941255,0.00004623424,0.003033224,0.000223565],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974142,0.0003168163,0.00001542648,0.0002638369,0.0002377505,0.001236495,0.0001317961,0.00001004781,0.0003736435],"genre_scores_gemma":[0.9983637,0.00005200278,0.0002114884,0.0001326723,0.00009981386,0.000105449,0.000782401,0.00002185817,0.0002306294],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2089591,"threshold_uncertainty_score":0.4534072,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008596450704891333,"score_gpt":0.2031214575849355,"score_spread":0.1945250068800441,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}