{"id":"W4310128829","doi":"10.1161/circep.122.010915","title":"First Randomized, Multicenter, Placebo-Controlled Study of Self-Administered Intranasal Etripamil for Acute Conversion of Spontaneous Paroxysmal Supraventricular Tachycardia (NODE-301)","year":2022,"lang":"en","type":"article","venue":"Circulation Arrhythmia and Electrophysiology","topic":"Cardiac Arrhythmias and Treatments","field":"Medicine","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Heart Institute; Cambridge Cardiac Care Centre; University of British Columbia; Centre Hospitalier de l’Université de Montréal; Vertex Pharmaceuticals (Canada)","funders":"","keywords":"Medicine; Placebo; Anesthesia; Clinical endpoint; Supraventricular tachycardia; Adverse effect; Randomized controlled trial; Multicenter trial; Tachycardia; Internal medicine; Multicenter study","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003548645,0.0002739494,0.00187136,0.0002495029,0.0002581419,0.000006965968,0.00005838312,0.0001043043,0.00005546905],"category_scores_gemma":[0.00009330396,0.0002373024,0.0005792932,0.0002108048,0.0000914012,0.00004357774,0.00006794222,0.000180492,0.000001189968],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001585826,"about_ca_system_score_gemma":0.0001153496,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006055547,"about_ca_topic_score_gemma":0.000003040434,"domain_scores_codex":[0.9976729,0.0004618444,0.000758712,0.0004632435,0.0002999566,0.0003433997],"domain_scores_gemma":[0.9983209,0.0005881776,0.0004804173,0.0003135871,0.000187193,0.0001096747],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9526963,0.001775031,0.004469447,0.0003738509,0.01012088,0.002173484,0.002424497,0.007131256,0.01797857,0.0002624476,0.00006939047,0.0005248432],"study_design_scores_gemma":[0.909364,0.007211268,0.01818868,0.00002776055,0.007300744,0.0029297,0.0007809606,0.05257906,0.0006685275,0.0001034522,0.0004653062,0.0003804723],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934277,0.0004385912,0.0005751328,0.0001377056,0.0003159684,0.004955477,0.00007518537,0.00003853665,0.0000357278],"genre_scores_gemma":[0.9984082,0.0001901771,0.0002432635,0.00006309566,0.000149544,0.000628471,0.0002540249,0.00003170792,0.00003154324],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0454478,"threshold_uncertainty_score":0.9676912,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006619915439815908,"score_gpt":0.2481266284027613,"score_spread":0.2415067129629453,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}