{"id":"W4310128829","doi":"10.1161/circep.122.010915","title":"First Randomized, Multicenter, Placebo-Controlled Study of Self-Administered Intranasal Etripamil for Acute Conversion of Spontaneous Paroxysmal Supraventricular Tachycardia (NODE-301)","year":2022,"lang":"en","type":"article","venue":"Circulation Arrhythmia and Electrophysiology","topic":"Cardiac Arrhythmias and Treatments","field":"Medicine","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Heart Institute; Cambridge Cardiac Care Centre; University of British Columbia; Centre Hospitalier de l’Université de Montréal; Vertex Pharmaceuticals (Canada)","funders":"","keywords":"Medicine; Placebo; Anesthesia; Clinical endpoint; Supraventricular tachycardia; Adverse effect; Randomized controlled trial; Multicenter trial; Tachycardia; Internal medicine; Multicenter study","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002476822,0.001952343,0.003862386,0.0004703303,0.0006727509,0.0009569209,0.001249287,0.002194543,0.005124852],"category_scores_gemma":[0.002546839,0.0008882369,0.001497466,0.0003424,0.001285466,0.001028788,0.000355287,0.002717758,0.0009957493],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000643527,"about_ca_system_score_gemma":0.001690181,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007501867,"about_ca_topic_score_gemma":0.001910187,"domain_scores_codex":[0.9988933,0.000577611,0.00008634269,0.0002149236,0.0000998815,0.0001278836],"domain_scores_gemma":[0.9982116,0.0004926734,0.0003822162,0.0001978275,0.0002094254,0.0005062422],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9729004,0.01352253,0.0004588121,0.0004000968,0.0006364923,0.0000367576,0.00005035561,0.00009498819,0.004164753,0.00005756826,0.0004448931,0.007232298],"study_design_scores_gemma":[0.9351207,0.06314982,0.0009084385,0.00001212894,0.0001768608,0.00001368204,0.000007217418,0.0001176832,0.0002563043,0.00002576223,0.0002052453,0.000006105467],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9808911,0.003156425,0.001247019,0.0005549671,0.0009194318,0.01003536,0.001330202,0.0001997698,0.001665756],"genre_scores_gemma":[0.9766014,0.001865629,0.003529136,0.00147759,0.0009593131,0.01165931,0.001228761,0.00004480802,0.002634183],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005124852,"threshold_uncertainty_score":0.01714426,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006619915439815908,"score_gpt":0.2481266284027613,"score_spread":0.2415067129629453,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}