{"id":"W4310159991","doi":"10.1182/blood-2022-163335","title":"Daratumumab Plus Lenalidomide and Dexamethasone (D-Rd) Versus Lenalidomide and Dexamethasone (Rd) Alone in Transplant-Ineligible Patients with Newly Diagnosed Multiple Myeloma (NDMM): Updated Analysis of the Phase 3 Maia Study","year":2022,"lang":"en","type":"article","venue":"Blood","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":41,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Cancer Research; University of Alberta; University of Calgary","funders":"","keywords":"Lenalidomide; Daratumumab; Dexamethasone; Medicine; Multiple myeloma; Internal medicine; Oncology; Thalidomide; Ixazomib; Carfilzomib","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003424024,0.0008270977,0.00228501,0.0004214785,0.0002956452,0.001458508,0.0009099169,0.0007112978,0.002012651],"category_scores_gemma":[0.003258086,0.0004265961,0.003985324,0.0008510655,0.000448688,0.001110217,0.0005642462,0.002348889,0.0002894833],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001109008,"about_ca_system_score_gemma":0.001117465,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001704443,"about_ca_topic_score_gemma":0.005978851,"domain_scores_codex":[0.998876,0.0006313259,0.00008814729,0.0001686598,0.0001160127,0.0001198479],"domain_scores_gemma":[0.9975882,0.0009800344,0.0008095028,0.0001794058,0.0001157039,0.0003272528],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.791181,0.001777937,0.05338704,0.002032923,0.02202708,0.0001023159,0.0001891814,0.002325081,0.003366028,0.0004505425,0.006211136,0.1169497],"study_design_scores_gemma":[0.5685637,0.09318982,0.2607236,0.0009395433,0.0518657,0.0006238711,0.0002726881,0.002629218,0.002071264,0.001804714,0.01716212,0.0001538179],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9444867,0.04218139,0.0006956875,0.0012561,0.0004693003,0.0005941288,0.007095397,0.00007584561,0.003145505],"genre_scores_gemma":[0.9832569,0.007644393,0.0009491842,0.001432676,0.0002981996,0.0003958192,0.004986233,0.00002816513,0.00100843],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003424024,"threshold_uncertainty_score":0.01810813,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02020970116908737,"score_gpt":0.2842972444813167,"score_spread":0.2640875433122293,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}