{"id":"W4310163212","doi":"10.1182/blood-2022-158650","title":"A Phase 1-2, Open-Label Study of the Safety, Pharmacokinetics, Pharmacodynamics, and Preliminary Activity of Tolinapant in Combination with Oral Decitabine/Cedazuridine and Oral Decitabine/Cedazuridine Alone in Subjects with Relapsed/Refractory Peripheral T-Cell Lymphoma","year":2022,"lang":"en","type":"article","venue":"Blood","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Decitabine; Pharmacodynamics; Pharmacokinetics; Medicine; Pharmacology; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001444631,0.001862449,0.002582204,0.0006182657,0.0006115174,0.0009373106,0.0008467077,0.001175918,0.0033935],"category_scores_gemma":[0.001063448,0.0007951478,0.001222985,0.000529853,0.00166084,0.001538216,0.0003484752,0.003896125,0.0009079078],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001052888,"about_ca_system_score_gemma":0.001371737,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009302877,"about_ca_topic_score_gemma":0.00207727,"domain_scores_codex":[0.9994035,0.000274208,0.00002186309,0.0001345637,0.00004775802,0.000118113],"domain_scores_gemma":[0.9991686,0.0001564202,0.0001464139,0.00009924352,0.00004847133,0.0003808372],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8112325,0.09859361,0.003314888,0.0003268636,0.0006256262,0.0001728003,0.000281676,0.001061193,0.04508672,0.0001695245,0.001146414,0.03798827],"study_design_scores_gemma":[0.3289256,0.6565294,0.008041526,0.0000112727,0.0003165413,0.0001606869,0.00007372172,0.0008217648,0.003708607,0.0001428066,0.001237118,0.00003081311],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996277,0.0007264736,0.000478323,0.0001578079,0.00006934032,0.001026787,0.0005409379,0.00006461158,0.0006586175],"genre_scores_gemma":[0.9932169,0.0007174181,0.001170839,0.0003455049,0.0001899841,0.001319327,0.001274998,0.00003514004,0.001729866],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0033935,"threshold_uncertainty_score":0.01135242,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01855229491883769,"score_gpt":0.2878997877042945,"score_spread":0.2693474927854568,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}