{"id":"W4310195633","doi":"10.1016/j.ijpharm.2022.122428","title":"Highly water-soluble dapsone nanocrystals: Towards innovative preparations for an undermined drug","year":2022,"lang":"en","type":"article","venue":"International Journal of Pharmaceutics","topic":"Surfactants and Colloidal Systems","field":"Chemistry","cited_by":24,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Fundação de Amparo à Pesquisa do Estado de São Paulo","keywords":"Dapsone; Drug; Nanocrystal; Chemistry; Drug carrier; Pharmaceutical technology; Nanotechnology; Pharmacology; Materials science; Chromatography; Medicine; Dermatology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002730469,0.0002668091,0.0001715514,0.0001207088,0.00009233982,0.0003136198,0.0001568281,0.0003110743,0.0006792056],"category_scores_gemma":[0.000227509,0.0001305348,0.0001245642,0.00007163134,0.0001727289,0.000293905,0.0002692893,0.0003727158,0.0003036854],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002864676,"about_ca_system_score_gemma":0.0001959183,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000331392,"about_ca_topic_score_gemma":0.0007224208,"domain_scores_codex":[0.9998933,0.00001780351,0.000008784323,0.00003064247,0.00003236993,0.00001701222],"domain_scores_gemma":[0.9999118,0.00002341817,0.00002121604,0.000008263758,0.00001891781,0.00001637281],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002750905,0.000008819353,0.00004560111,0.00004344898,0.00000369142,0.00003175156,0.00001701073,0.00005656022,0.9963762,0.0001811233,0.00003967591,0.003168608],"study_design_scores_gemma":[0.000006838026,0.0001232319,0.0001651446,0.000003157476,0.000006938413,0.00007819455,0.000008252105,0.0004970824,0.9965476,0.00002534053,0.002535499,0.000002639869],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9396262,0.004976873,0.04897619,0.0003648176,0.00008940401,0.000202411,0.000192278,0.0001744538,0.005397393],"genre_scores_gemma":[0.9643721,0.002398089,0.02724156,0.0001355981,0.00002343162,0.00005950328,0.000149614,0.00003873983,0.005581292],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006792056,"threshold_uncertainty_score":0.002272129,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06144953519479359,"score_gpt":0.372377286073206,"score_spread":0.3109277508784125,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}