{"id":"W4310211651","doi":"10.3390/antiox11122345","title":"Nrf2 and Oxidative Stress: A General Overview of Mechanisms and Implications in Human Disease","year":2022,"lang":"en","type":"review","venue":"Antioxidants","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":964,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Oxidative stress; Reactive oxygen species; Antioxidant; Transcription factor; Disease; Biology; Oxidative phosphorylation; Regulator; Cell biology; Biochemistry; Medicine; Internal medicine; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004954068,0.0007410637,0.001076356,0.001826904,0.0003308828,0.0008458904,0.0007636859,0.0009949807,0.005743299],"category_scores_gemma":[0.0005414635,0.0002159779,0.0004410442,0.002046728,0.0003801417,0.001618997,0.0006765675,0.001451376,0.002512501],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006213787,"about_ca_system_score_gemma":0.001130307,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009196075,"about_ca_topic_score_gemma":0.001592769,"domain_scores_codex":[0.9998735,0.00002425439,0.00001908576,0.00002677846,0.00004087162,0.00001543561],"domain_scores_gemma":[0.9998031,0.00009014214,0.00002361945,0.000006174507,0.0000531791,0.00002384596],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001136271,0.00006328405,0.0002327432,0.02433787,0.00008268947,0.0003392105,0.0001384034,0.0002844893,0.002972526,0.006817521,0.05632405,0.9082937],"study_design_scores_gemma":[0.000007349486,0.00006430054,0.0005533007,0.002920874,0.00005208061,0.0009433827,0.0000561489,0.00003418065,0.0003059879,0.002532449,0.9925168,0.00001318534],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00009735431,0.9979741,0.0001576118,0.000425657,0.0002313057,0.000005736128,0.0000368732,0.00001054498,0.001060809],"genre_scores_gemma":[0.0004340479,0.9984207,0.0001569165,0.0001757851,0.0001819714,0.000006928442,0.00004484793,0.000001452591,0.0005773438],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.005743299,"threshold_uncertainty_score":0.01921326,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05697575357657537,"score_gpt":0.3505516107782647,"score_spread":0.2935758572016894,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}