{"id":"W4310251723","doi":"10.1126/science.abm0271","title":"A multivalent nucleoside-modified mRNA vaccine against all known influenza virus subtypes","year":2022,"lang":"en","type":"article","venue":"Science","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":348,"is_retracted":false,"has_abstract":true,"ca_institutions":"Acuitas Therapeutics (Canada)","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"Virology; Nucleoside; Virus; Messenger RNA; Influenza A virus; Chemistry; Biology; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000093693,0.0003009071,0.000168213,0.0001201294,0.0001039911,0.0001772406,0.0001474879,0.0002459548,0.0007969551],"category_scores_gemma":[0.00009203637,0.00007404361,0.0001718001,0.00005758253,0.0001624151,0.0001988719,0.000175667,0.0003674695,0.0002315027],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002149752,"about_ca_system_score_gemma":0.0001796845,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002999796,"about_ca_topic_score_gemma":0.0006457221,"domain_scores_codex":[0.9999331,0.000006691771,0.000004404574,0.00002116122,0.00002223984,0.00001230515],"domain_scores_gemma":[0.9999554,0.000007137553,0.00001454774,0.000004342882,0.000008525442,0.00001003465],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002939771,0.00002232145,0.0001480785,0.00002712804,0.000005083455,0.00002183005,0.00000817042,0.0001346892,0.9947538,0.0001241273,0.00002680864,0.004698512],"study_design_scores_gemma":[0.00001878556,0.001179627,0.001146881,0.000008865889,0.0000416636,0.0002775147,0.00001980357,0.001023893,0.9912282,0.0000937373,0.004955268,0.000005720723],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9749824,0.002344223,0.01928704,0.0001656653,0.0001009062,0.00007519478,0.0001156171,0.0001047205,0.002824148],"genre_scores_gemma":[0.9830892,0.0009952558,0.01264576,0.00009719564,0.00002282223,0.00003696512,0.0001813438,0.00001572536,0.002915802],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007969551,"threshold_uncertainty_score":0.002666056,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06123286314738047,"score_gpt":0.3762085912704339,"score_spread":0.3149757281230535,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}