{"id":"W4310251723","doi":"10.1126/science.abm0271","title":"A multivalent nucleoside-modified mRNA vaccine against all known influenza virus subtypes","year":2022,"lang":"en","type":"article","venue":"Science","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":348,"is_retracted":false,"has_abstract":true,"ca_institutions":"Acuitas Therapeutics (Canada)","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"Virology; Nucleoside; Virus; Messenger RNA; Influenza A virus; Chemistry; Biology; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001227732,0.0001521549,0.0002219366,0.0003840025,0.0005205921,0.00006452707,0.0006809305,0.00003289635,0.00008244594],"category_scores_gemma":[0.0007639145,0.0001295115,0.00008284594,0.00137253,0.0002663262,0.0001491071,0.0006406031,0.0004093286,0.0001966851],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003698337,"about_ca_system_score_gemma":0.0007854225,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002810058,"about_ca_topic_score_gemma":0.00004019261,"domain_scores_codex":[0.99711,0.00005978573,0.000256827,0.0005839785,0.001350931,0.0006384624],"domain_scores_gemma":[0.9989049,0.0000880205,0.00006930299,0.0005979228,0.0002190289,0.0001208088],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003615387,0.0002992166,0.01970444,0.00003256154,0.00001793644,0.0001232339,0.0007387102,0.00004297219,0.967519,0.0002720747,0.0009776521,0.009910617],"study_design_scores_gemma":[0.002087041,0.0004521838,0.03997912,0.00002864057,0.00001973425,0.00002766442,0.0002881911,0.00447178,0.2822353,0.0001671715,0.6700088,0.000234429],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9865307,0.000644659,0.00001090159,0.000499917,0.00035538,0.0004234675,0.00001092055,0.0001100627,0.01141405],"genre_scores_gemma":[0.9386072,0.000007899174,0.0001300888,0.06091363,0.0001159937,0.00007085856,0.000001179219,0.00001782552,0.0001353826],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6852838,"threshold_uncertainty_score":0.5281326,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06123286314738047,"score_gpt":0.3762085912704339,"score_spread":0.3149757281230535,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}