{"id":"W4310275049","doi":"10.1038/s41541-022-00572-z","title":"A highly immunogenic vaccine platform against encapsulated pathogens using chimeric probiotic Escherichia coli membrane vesicles","year":2022,"lang":"en","type":"article","venue":"npj Vaccines","topic":"Pneumonia and Respiratory Infections","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; Umeå Universitet; Japan Society for the Promotion of Science; Ministry of Education, Culture, Sports, Science and Technology; Japan Agency for Medical Research and Development; Karolinska Institutet; Nihon University","keywords":"Immunogenicity; Immune system; Adjuvant; Biology; Microbiology; Escherichia coli; Antigen; ELISPOT; Vaccination; Virology; Immunology; T cell; Biochemistry; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001146275,0.0003251059,0.0001788991,0.0001172087,0.00008614692,0.0002280825,0.0001851394,0.0003322997,0.0003181651],"category_scores_gemma":[0.00006648623,0.0001170619,0.0002516943,0.00008155711,0.0001097436,0.0001970048,0.000279606,0.0002869607,0.000196026],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001903826,"about_ca_system_score_gemma":0.0001378706,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000191862,"about_ca_topic_score_gemma":0.0001728672,"domain_scores_codex":[0.9999429,0.00001164324,0.000004834528,0.00001098366,0.000013433,0.00001614754],"domain_scores_gemma":[0.9999696,0.000002232501,0.00001175941,0.000003067637,0.000005759911,0.000007519996],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002326334,0.00001162194,0.00006988023,0.00001773955,0.000003118441,0.00001640486,0.0000023711,0.0001488484,0.9989341,0.00009260266,0.00001184196,0.0006683358],"study_design_scores_gemma":[0.000008976977,0.0002498639,0.0005276385,0.000004443854,0.00001290782,0.0000962905,0.00000876066,0.001370976,0.9960535,0.00003745109,0.001625861,0.00000330948],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9844668,0.0007714778,0.01388001,0.00007491098,0.00003790158,0.00004660058,0.0001354686,0.00007306347,0.000513794],"genre_scores_gemma":[0.9890737,0.0004996366,0.009030652,0.00003315004,0.000006688166,0.00003279234,0.0002664459,0.00001143594,0.001045486],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0003322997,"threshold_uncertainty_score":0.001381278,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02006110471472865,"score_gpt":0.2526604921828822,"score_spread":0.2325993874681536,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}