{"id":"W4310276774","doi":"10.1007/s00401-022-02516-2","title":"Amplification of the PLAG-family genes—PLAGL1 and PLAGL2—is a key feature of the novel tumor type CNS embryonal tumor with PLAGL amplification","year":2022,"lang":"en","type":"article","venue":"Acta Neuropathologica","topic":"Neuroblastoma Research and Treatments","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Cancer Institute; Medical Research Council; Deutsche Kinderkrebsstiftung; Brain Tumour Charity; Deutsches Krebsforschungszentrum","keywords":"Biology; Gene; Feature (linguistics); Pathology; Cancer research; Genetics; Molecular biology; Medicine; Philosophy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000938595,0.0002932403,0.0001678591,0.0004418079,0.00012741,0.0002173771,0.0001807477,0.0001581859,0.0006036694],"category_scores_gemma":[0.000224523,0.0001254695,0.0001384934,0.000356757,0.0002534404,0.0001566081,0.0001985193,0.0002154337,0.0001542124],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002074843,"about_ca_system_score_gemma":0.000197978,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008478573,"about_ca_topic_score_gemma":0.001851599,"domain_scores_codex":[0.9998927,0.000005807952,0.000007267456,0.00004525168,0.00003460054,0.00001442089],"domain_scores_gemma":[0.9998659,0.00001536951,0.00007785128,0.00001155119,0.00001303298,0.00001639312],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002050523,0.00001302226,0.1311141,0.00009787279,0.0000490799,0.005849664,0.000113743,0.0004722652,0.8461281,0.0002073448,0.0002298931,0.01551972],"study_design_scores_gemma":[0.00001609117,0.0001685961,0.5789754,0.00001538237,0.0001287994,0.07607675,0.0001868663,0.003431968,0.3349191,0.0004462156,0.005614605,0.00002033245],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924104,0.0005123095,0.005488689,0.0000454287,0.000003831046,0.00002348266,0.0006249894,0.0001212006,0.0007697651],"genre_scores_gemma":[0.9941163,0.0004296155,0.004110644,0.00002004117,0.000006248582,0.00001918274,0.000745189,0.00001345528,0.0005391705],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008478573,"threshold_uncertainty_score":0.002019525,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02669211058498748,"score_gpt":0.2490652228214528,"score_spread":0.2223731122364653,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}