{"id":"W4310340633","doi":"10.1101/2022.11.28.518141","title":"Noncannonical functions of Ku may underlie essentiality in human cells","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Ku70; Telomere; Biology; Ku80; DNA repair; Knockout mouse; Cell biology; Molecular biology; Genetics; DNA; Gene; DNA-binding protein; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000230836,0.0002721624,0.0002643578,0.0003445888,0.0002665048,0.0005280894,0.0002116534,0.0003276593,0.002431765],"category_scores_gemma":[0.0003793025,0.0001200226,0.0002780289,0.0002676377,0.0002545903,0.0002244761,0.0004279352,0.000496218,0.0006132559],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002840677,"about_ca_system_score_gemma":0.0002407041,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003976634,"about_ca_topic_score_gemma":0.0004350319,"domain_scores_codex":[0.9997817,0.00002775591,0.00002521776,0.00006298259,0.00005299919,0.00004929765],"domain_scores_gemma":[0.9996551,0.00004809561,0.0001187387,0.00008058632,0.00005537672,0.0000421132],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002532161,0.00002479271,0.00237771,0.0001052751,0.00001913849,0.000376924,0.0000674236,0.0001031885,0.9914185,0.0006130401,0.000233083,0.004407611],"study_design_scores_gemma":[0.00002805036,0.0003322044,0.06420313,0.00004012797,0.00008299228,0.004628121,0.0002207051,0.001744965,0.906965,0.001167854,0.02056164,0.00002525605],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9810517,0.004976369,0.008586209,0.0002989849,0.00007007649,0.00004957703,0.001477448,0.0002838447,0.003205758],"genre_scores_gemma":[0.9957416,0.0008654637,0.001054312,0.00006773569,0.00000880551,0.00002220304,0.0007862478,0.0000230657,0.001430544],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002431765,"threshold_uncertainty_score":0.00813514,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01192350843131173,"score_gpt":0.27245889890799,"score_spread":0.2605353904766783,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}