{"id":"W4310356826","doi":"10.1101/2022.11.23.517695","title":"Multivalent Human Cytomegalovirus Glycoprotein B Nucleoside-Modified mRNA Vaccines Demonstrate a Greater Breadth in T cell but not Antibody Responses","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cytomegalovirus and herpesvirus research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Acuitas Therapeutics (Canada)","funders":"","keywords":"Virology; Human cytomegalovirus; Immunogenicity; Biology; Antibody; Antigen; Nucleoside; Virus; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001376787,0.0003842032,0.0002393719,0.0001500849,0.00007684426,0.000219984,0.00009861817,0.0003138222,0.001516027],"category_scores_gemma":[0.000137781,0.0001113214,0.0001753415,0.00005990363,0.0001461143,0.0001676769,0.0001825047,0.0006393343,0.0003051877],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001874328,"about_ca_system_score_gemma":0.0001039805,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002659981,"about_ca_topic_score_gemma":0.0003427445,"domain_scores_codex":[0.9998279,0.00002314037,0.00001223453,0.00004962712,0.00003335158,0.00005365173],"domain_scores_gemma":[0.9999042,0.00002672677,0.00001814352,0.00001267526,0.00001551234,0.0000228267],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000897369,0.00004944743,0.000153008,0.00002710276,0.000005358156,0.00001309878,0.00001201149,0.00004780649,0.9980106,0.00003137203,0.00002431657,0.001536324],"study_design_scores_gemma":[0.00007115287,0.003900487,0.006315198,0.00001990023,0.00006476998,0.0003371655,0.00004444241,0.0009603453,0.9852839,0.00008646995,0.002910289,0.00000596757],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970393,0.0008312587,0.0010307,0.00004277037,0.00003728019,0.00002165679,0.00006223973,0.00003254909,0.000902241],"genre_scores_gemma":[0.99717,0.0003569152,0.0007858698,0.00007466641,0.00002045569,0.00002433739,0.000141095,0.000009723482,0.001417013],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001516027,"threshold_uncertainty_score":0.00507158,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03669844866852823,"score_gpt":0.3066453416904807,"score_spread":0.2699468930219525,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}