{"id":"W4310453889","doi":"10.1016/j.isci.2022.105698","title":"Macrophage ferroportin serves as a therapeutic target against bacteria-induced acute lung injury by promoting barrier restoration","year":2022,"lang":"en","type":"article","venue":"iScience","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Health Commission of the People's Republic of China; Chinese Academy of Medical Sciences; Zhejiang University; Ministry of Education of the People's Republic of China; School of Medicine; Fudan University; National Natural Science Foundation of China; BC Children's Hospital","keywords":"ARDS; Ferroportin; Macrophage; Lung; Cancer research; Inflammation; Immunology; Hepcidin; Medicine; Biology; Cell biology; Microbiology; Chemistry; Internal medicine; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007519206,0.0001539825,0.0001002856,0.00003736938,0.0004939039,0.00008815149,0.0004907194,0.0000644757,0.0001597434],"category_scores_gemma":[0.0001209621,0.0001591936,0.00006800562,0.0002271314,0.0001254942,0.00002078919,0.0003629676,0.0001692,0.000009794925],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006032268,"about_ca_system_score_gemma":0.0002124477,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008180188,"about_ca_topic_score_gemma":0.000001089395,"domain_scores_codex":[0.998287,0.0003053707,0.0002504072,0.0005184154,0.0003220515,0.0003167066],"domain_scores_gemma":[0.9991981,0.000007710458,0.0001732924,0.000436264,0.00004306285,0.0001416116],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004840764,0.00007181337,0.001222691,0.00000793435,0.00001599974,0.00002321888,0.0002165036,0.0000309971,0.9949972,0.00001601828,0.000968329,0.002380882],"study_design_scores_gemma":[0.0001920225,0.0002555975,0.000821139,0.000004541718,0.00001472927,0.00001476742,0.0001650088,0.0017773,0.987904,0.00009841884,0.008515539,0.0002369697],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971461,0.001299914,0.0003715306,0.0001800278,0.0002532548,0.0002833863,0.00008973231,0.00002904924,0.0003469614],"genre_scores_gemma":[0.9973894,0.00001775443,0.0003978711,0.0008035791,0.00007373108,0.00007900383,0.0001802418,0.00002601446,0.001032438],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00754721,"threshold_uncertainty_score":0.6491727,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00790585941230833,"score_gpt":0.270519406225713,"score_spread":0.2626135468134047,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}