{"id":"W4310459994","doi":"10.1007/s00432-022-04440-0","title":"Nutrient deprivation and hypoxia alter T cell immune checkpoint expression: potential impact for immunotherapy","year":2022,"lang":"en","type":"article","venue":"Journal of Cancer Research and Clinical Oncology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Trinity College","funders":"Irish Research Council; Irish Research Council for Science, Engineering and Technology","keywords":"Immune system; Immune checkpoint; Nivolumab; Cancer research; Downregulation and upregulation; Tumor microenvironment; Immunotherapy; Cytotoxic T cell; TIGIT; T cell; Stromal cell; Immunology; Biology; Medicine; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004682209,0.0001087562,0.0005574691,0.0001901451,0.0002815885,0.00002643756,0.0001441776,0.0001233528,0.0006450697],"category_scores_gemma":[0.0001320635,0.00007576076,0.0003510492,0.0001704305,0.0003157799,0.00008259337,0.0001195428,0.0009536237,3.926421e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004505963,"about_ca_system_score_gemma":0.001135256,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000112271,"about_ca_topic_score_gemma":0.000008090117,"domain_scores_codex":[0.9975218,0.0003948463,0.001030896,0.0002083422,0.0005168691,0.0003272451],"domain_scores_gemma":[0.9980253,0.0006741346,0.0004978256,0.000156877,0.0004106054,0.0002352799],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.156366,0.001941388,0.008299876,0.00008194691,0.0006588176,0.0001177159,0.0003583413,0.000013403,0.5978579,0.00001797603,0.007673489,0.2266131],"study_design_scores_gemma":[0.08838427,0.1300534,0.286824,0.0002583938,0.0002106455,0.001162219,0.002235251,0.0003495853,0.05982997,0.004476666,0.4258256,0.0003900322],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9649708,0.0231895,0.0003178331,0.0103323,0.0005383902,0.0005321943,0.00001845326,0.000004008265,0.00009654261],"genre_scores_gemma":[0.964213,0.03339392,0.0006344873,0.0005501817,0.000719325,0.00007749968,0.000005164295,0.00001934583,0.0003871511],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5380279,"threshold_uncertainty_score":0.7063061,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08980063267757109,"score_gpt":0.4944848289899192,"score_spread":0.4046841963123481,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}