{"id":"W4310463630","doi":"10.7150/thno.77528","title":"Signatures of EMT, immunosuppression, and inflammation in primary and recurrent human cutaneous squamous cell carcinoma at single-cell resolution","year":2022,"lang":"en","type":"article","venue":"Theranostics","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"SKiN Health","funders":"National Postdoctoral Program for Innovative Talents; China Postdoctoral Science Foundation; National Natural Science Foundation of China","keywords":"Tumor microenvironment; Cancer research; Midkine; Cell growth; Angiogenesis; Biology; Metastasis; Cell; Epithelial–mesenchymal transition; Immunology; Cancer; Growth factor; Immune system; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000168707,0.00009040746,0.0002931729,0.0004089007,0.0001510908,0.0002967468,0.0001030871,0.0002272783,0.0005983259],"category_scores_gemma":[0.0001926554,0.0001266115,0.0001860098,0.0003157923,0.0001297559,0.0001329785,0.0001610851,0.00019468,0.0002100409],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001731455,"about_ca_system_score_gemma":0.0001322423,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000755122,"about_ca_topic_score_gemma":0.001148762,"domain_scores_codex":[0.9998871,0.000009565208,0.000007942997,0.00003191329,0.00003749869,0.00002591147],"domain_scores_gemma":[0.9998866,0.00001687157,0.00002404515,0.00001421214,0.00003430564,0.00002392223],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001594249,0.0000207977,0.01009149,0.0001021438,0.00001879806,0.0002208285,0.0001908383,0.000414895,0.9842047,0.000102697,0.0000949672,0.004378458],"study_design_scores_gemma":[0.00002642832,0.0004385918,0.436942,0.00002665113,0.0001202531,0.00211666,0.0007818406,0.01537448,0.5402676,0.0003088331,0.003564989,0.00003171816],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964503,0.0005981741,0.001865611,0.0000207118,0.000005159908,0.00001792612,0.0004952569,0.00005449744,0.0004923182],"genre_scores_gemma":[0.9960899,0.0002788014,0.00231204,0.00002791258,0.000007023605,0.00003447769,0.0007413101,0.0000127281,0.0004957466],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000755122,"threshold_uncertainty_score":0.002001524,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01267488799260181,"score_gpt":0.2265062656141187,"score_spread":0.2138313776215169,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}