{"id":"W4310463630","doi":"10.7150/thno.77528","title":"Signatures of EMT, immunosuppression, and inflammation in primary and recurrent human cutaneous squamous cell carcinoma at single-cell resolution","year":2022,"lang":"en","type":"article","venue":"Theranostics","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"SKiN Health","funders":"National Postdoctoral Program for Innovative Talents; China Postdoctoral Science Foundation; National Natural Science Foundation of China","keywords":"Tumor microenvironment; Cancer research; Midkine; Cell growth; Angiogenesis; Biology; Metastasis; Cell; Epithelial–mesenchymal transition; Immunology; Cancer; Growth factor; Immune system; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001297144,0.0001141304,0.0002258971,0.0001051066,0.00008681076,0.000006156558,0.00004401018,0.00005065729,0.000044095],"category_scores_gemma":[0.00001963448,0.0001079723,0.0000294526,0.00009560429,0.00006316496,0.00002252551,0.0001281285,0.0002004791,2.504885e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002299213,"about_ca_system_score_gemma":0.00004331335,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001061761,"about_ca_topic_score_gemma":0.0000305409,"domain_scores_codex":[0.9990933,0.0000889209,0.0002730846,0.0001795568,0.0002223643,0.0001428018],"domain_scores_gemma":[0.9995036,0.0001036055,0.0001334113,0.0001715623,0.00003890631,0.00004890727],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009046783,0.0002273705,0.003934492,0.0004183084,0.000004918727,0.00005139398,0.001690583,0.0001721255,0.9865025,0.00002006458,0.0004073615,0.005666216],"study_design_scores_gemma":[0.0122921,0.005748378,0.0635503,0.0002078417,0.0004859397,0.0003449414,0.00106124,0.001030099,0.8865443,0.0002841694,0.02784273,0.0006079988],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9822406,0.01628926,0.00001365635,0.00008520069,0.0001135861,0.0003527247,0.00003083213,0.0000265222,0.0008475835],"genre_scores_gemma":[0.999051,0.000288873,0.0001609497,0.00005454918,0.00004530652,0.00001100201,0.00007298331,0.00003225022,0.0002831331],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09995823,"threshold_uncertainty_score":0.4402982,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01267488799260181,"score_gpt":0.2265062656141187,"score_spread":0.2138313776215169,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}