{"id":"W4310465099","doi":"10.1097/j.pain.0000000000002806","title":"Monoaminergic mediation of hyperalgesic and analgesic descending control of nociception in mice","year":2022,"lang":"en","type":"article","venue":"Pain","topic":"Pain Mechanisms and Treatments","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"Reboxetine; Neurochemical; Nociception; Pharmacology; Monoaminergic; Analgesic; Monoamine neurotransmitter; Noxious stimulus; Norepinephrine; Chronic pain; Fluoxetine; Neuroscience; Serotonin; Chemistry; Psychology; Anesthesia; Reuptake inhibitor; Medicine; Receptor; Internal medicine; Dopamine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001240734,0.00005080977,0.0001696689,0.0001315866,0.00002200009,9.716622e-7,0.00002047381,0.00001846639,0.00004019778],"category_scores_gemma":[0.0001103485,0.00004844557,0.0000244773,0.0001454638,0.00001155892,0.00002145566,0.00001078922,0.00005366738,3.767187e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005692915,"about_ca_system_score_gemma":0.00001669987,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008734658,"about_ca_topic_score_gemma":0.000008053588,"domain_scores_codex":[0.9992584,0.0002775954,0.0001631615,0.00009177891,0.0001319787,0.00007706873],"domain_scores_gemma":[0.9996406,0.0001750939,0.00008597402,0.00005731104,0.00001570342,0.00002529518],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002517742,0.0003378108,0.4622389,0.0001446012,0.00006747278,0.00002343802,0.0008549455,0.0001610555,0.5009456,0.0008294546,0.00002374852,0.03412119],"study_design_scores_gemma":[0.01353163,0.001901027,0.833339,0.0001397007,0.0002717773,0.00002533164,0.002603985,0.1224876,0.02328605,0.002118225,0.00007728778,0.0002182937],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955457,0.0004819962,0.003504038,0.0001629544,0.00002423497,0.0001956289,0.000009133141,0.000006404835,0.00006990325],"genre_scores_gemma":[0.9992974,0.00003502199,0.0004655209,0.00009719573,0.0000121882,0.0000282367,0.00002665048,0.000005986627,0.0000317375],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4776596,"threshold_uncertainty_score":0.1975553,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009659271305477151,"score_gpt":0.2336625910541566,"score_spread":0.2240033197486795,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}