{"id":"W4310465099","doi":"10.1097/j.pain.0000000000002806","title":"Monoaminergic mediation of hyperalgesic and analgesic descending control of nociception in mice","year":2022,"lang":"en","type":"article","venue":"Pain","topic":"Pain Mechanisms and Treatments","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"Reboxetine; Neurochemical; Nociception; Pharmacology; Monoaminergic; Analgesic; Monoamine neurotransmitter; Noxious stimulus; Norepinephrine; Chronic pain; Fluoxetine; Neuroscience; Serotonin; Chemistry; Psychology; Anesthesia; Reuptake inhibitor; Medicine; Receptor; Internal medicine; Dopamine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00042436,0.0007301296,0.0005360625,0.001159667,0.0003720015,0.0005339788,0.0006618693,0.0009368593,0.00348128],"category_scores_gemma":[0.0001667055,0.0004833766,0.0008660115,0.0002477605,0.000579239,0.0005872961,0.0002720508,0.0025342,0.00103229],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000724802,"about_ca_system_score_gemma":0.0005255395,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001543853,"about_ca_topic_score_gemma":0.002541052,"domain_scores_codex":[0.9995443,0.00005687067,0.00005114611,0.0001203185,0.00009818737,0.0001291251],"domain_scores_gemma":[0.9996384,0.00002712199,0.0001136541,0.00004597693,0.00003665978,0.0001380352],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009773284,0.0004151145,0.0003815441,0.00007130345,0.00002317283,0.00008334016,0.00004232833,0.000043288,0.9957045,0.0001763576,0.0001622136,0.001919449],"study_design_scores_gemma":[0.0005231828,0.007447943,0.02142499,0.00008848881,0.0001433879,0.0007172442,0.0001667523,0.001528166,0.9618306,0.0002114793,0.005888982,0.00002881407],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9875284,0.003090626,0.003100445,0.0006511036,0.0001310353,0.000179639,0.002721412,0.0002546251,0.002342852],"genre_scores_gemma":[0.9695351,0.003743861,0.006423461,0.000810234,0.00007687153,0.0007614123,0.003476524,0.0001205752,0.01505188],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00348128,"threshold_uncertainty_score":0.01164603,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009659271305477151,"score_gpt":0.2336625910541566,"score_spread":0.2240033197486795,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}