{"id":"W4310465156","doi":"10.1093/jnci/djac215","title":"Body mass index and molecular subtypes of colorectal cancer","year":2022,"lang":"en","type":"article","venue":"JNCI Journal of the National Cancer Institute","topic":"Colorectal Cancer Screening and Detection","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland; Lunenfeld-Tanenbaum Research Institute; Ontario Institute for Cancer Research; University of Toronto; Mount Sinai Hospital","funders":"Niilo Helanderin Säätiö; Office of Research Infrastructure Programs, National Institutes of Health; Canadian Institutes of Health Research; Centers for Disease Control and Prevention; National Heart, Lung, and Blood Institute; Vetenskapsrådet; Cancer Council Victoria; Cancerfonden; Harvard T.H. Chan School of Public Health; Knut och Alice Wallenbergs Stiftelse; Fred Hutchinson Cancer Research Center; McGill University; National Cancer Institute; Brigham and Women's Hospital; National Health and Medical Research Council; Cancer Research UK; American Cancer Society; Bundesministerium für Bildung und Forschung; Centre International de Recherche sur le Cancer; World Health Organization; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"Microsatellite instability; Body mass index; Internal medicine; Colorectal cancer; KRAS; Odds ratio; Oncology; Medicine; Cancer; Obesity; Biology; Genetics; Allele; Microsatellite","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003036212,0.00008099056,0.0002009996,0.0001494075,0.000147849,0.00000861717,0.0001257117,0.00003403318,0.0001203117],"category_scores_gemma":[0.0001124651,0.00006040166,0.0001233859,0.0003468526,0.0000987099,0.0001056112,0.00006865161,0.0003652271,1.509497e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005411837,"about_ca_system_score_gemma":0.0009660047,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003061871,"about_ca_topic_score_gemma":0.0001056857,"domain_scores_codex":[0.9985774,0.00004424512,0.0002824113,0.00009666866,0.0009060849,0.00009318582],"domain_scores_gemma":[0.999024,0.00002891914,0.0003628839,0.00004818533,0.0004780792,0.00005788411],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.03115158,0.0003523371,0.3342429,0.0002744758,0.001664883,0.0001042779,0.0008521117,0.109877,0.4918438,0.00217056,0.0117829,0.0156832],"study_design_scores_gemma":[0.008208084,0.003464591,0.6899946,0.0004069014,0.0006584398,0.001952244,0.0002354248,0.006864122,0.1913897,0.003043466,0.09337264,0.0004097281],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929484,0.001960567,0.0001340024,0.002234441,0.001728446,0.0001332601,0.00005172646,0.000006121137,0.0008030978],"genre_scores_gemma":[0.9987024,0.0001158307,0.0001432196,0.0005359826,0.0003214462,0.0000280096,0.000001231893,0.000008580638,0.0001433025],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3557518,"threshold_uncertainty_score":0.2463108,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02193906566843235,"score_gpt":0.3074423885904218,"score_spread":0.2855033229219895,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}