{"id":"W4310465156","doi":"10.1093/jnci/djac215","title":"Body mass index and molecular subtypes of colorectal cancer","year":2022,"lang":"en","type":"article","venue":"JNCI Journal of the National Cancer Institute","topic":"Colorectal Cancer Screening and Detection","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland; Lunenfeld-Tanenbaum Research Institute; Ontario Institute for Cancer Research; University of Toronto; Mount Sinai Hospital","funders":"Niilo Helanderin Säätiö; Office of Research Infrastructure Programs, National Institutes of Health; Canadian Institutes of Health Research; Centers for Disease Control and Prevention; National Heart, Lung, and Blood Institute; Vetenskapsrådet; Cancer Council Victoria; Cancerfonden; Harvard T.H. Chan School of Public Health; Knut och Alice Wallenbergs Stiftelse; Fred Hutchinson Cancer Research Center; McGill University; National Cancer Institute; Brigham and Women's Hospital; National Health and Medical Research Council; Cancer Research UK; American Cancer Society; Bundesministerium für Bildung und Forschung; Centre International de Recherche sur le Cancer; World Health Organization; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"Microsatellite instability; Body mass index; Internal medicine; Colorectal cancer; KRAS; Odds ratio; Oncology; Medicine; Cancer; Obesity; Biology; Genetics; Allele; Microsatellite","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003112762,0.0004710121,0.0007635702,0.002196918,0.0002744772,0.000838489,0.0004649659,0.0004223355,0.001239058],"category_scores_gemma":[0.005674224,0.0002825263,0.001482036,0.002514967,0.0002962414,0.000267557,0.000527871,0.0005177847,0.0001534522],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003045323,"about_ca_system_score_gemma":0.0004339122,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002683588,"about_ca_topic_score_gemma":0.003509086,"domain_scores_codex":[0.9987963,0.000361636,0.0002186345,0.0002966753,0.0002378643,0.00008886273],"domain_scores_gemma":[0.9930735,0.001690413,0.003637744,0.0007047699,0.0004462884,0.0004473023],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000371972,0.000007559488,0.9954276,0.0001068725,0.001518746,0.00003204659,0.0000150803,0.0001329598,0.0002224322,0.00002714258,0.00006687236,0.002070568],"study_design_scores_gemma":[0.00001740896,0.00006796575,0.9981281,0.00003742163,0.0008428108,0.0002018715,0.00001913719,0.000203681,0.0000684734,0.00009089436,0.0003181493,0.000003998044],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9809276,0.01517667,0.000823036,0.0001844387,0.00006408732,0.00004980835,0.001701957,0.00002820319,0.001044277],"genre_scores_gemma":[0.9971848,0.001174045,0.0004261927,0.00004931613,0.00006690485,0.00002739228,0.0009562151,0.000007499061,0.0001075798],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003112762,"threshold_uncertainty_score":0.01646209,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02193906566843235,"score_gpt":0.3074423885904218,"score_spread":0.2855033229219895,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}