{"id":"W4310472863","doi":"10.46471/gigabyte.72","title":"PhysiPKPD: A pharmacokinetics and pharmacodynamics module for PhysiCell","year":2022,"lang":"en","type":"article","venue":"Gigabyte","topic":"Mathematical Biology Tumor Growth","field":"Mathematics","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Open source; Pharmacodynamics; In silico; Key (lock); Computer science; Source code; Pharmacokinetics; Code (set theory); Computational biology; Software engineering; Pharmacology; Medicine; Programming language; Biology; Operating system; Software","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003524519,0.0002030269,0.0003072993,0.00005804089,0.0002707055,0.00001939967,0.0002694381,0.00002966956,0.0002550773],"category_scores_gemma":[0.00008358483,0.0001985442,0.0001052328,0.0001524234,0.00009050834,0.00005325105,0.000306997,0.0002368187,0.00001180507],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004725389,"about_ca_system_score_gemma":0.00002201317,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001851114,"about_ca_topic_score_gemma":5.93006e-7,"domain_scores_codex":[0.998753,0.00008065197,0.0002703039,0.0003332594,0.0002063966,0.0003564174],"domain_scores_gemma":[0.9989352,0.0005221237,0.0001391118,0.0002623915,0.00004475937,0.00009643464],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0004537394,0.002047907,0.0002784604,0.001892857,0.0004894657,0.00003729692,0.002132504,0.0001608763,0.1767887,0.7285475,0.07505966,0.01211106],"study_design_scores_gemma":[0.003042441,0.0003227109,0.0000616076,0.00001471212,0.0002873958,0.00005168507,0.000209369,0.1089001,0.01602579,0.8409373,0.02956249,0.0005844042],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":"theoretical_or_conceptual","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9752485,0.0001880636,0.01601203,0.0009308733,0.0004548364,0.001437707,0.0003994093,0.000318791,0.005009844],"genre_scores_gemma":[0.9745318,0.00002001969,0.02157586,0.000742547,0.0002318979,0.0006030119,0.00003900964,0.00008323195,0.002172667],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1607629,"threshold_uncertainty_score":0.8096399,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03873704078232713,"score_gpt":0.3282084953522806,"score_spread":0.2894714545699535,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}