{"id":"W4310497533","doi":"10.1016/j.cgh.2022.11.029","title":"Upadacitinib Therapy Reduces Ulcerative Colitis Symptoms as Early as Day 1 of Induction Treatment","year":2022,"lang":"en","type":"article","venue":"Clinical Gastroenterology and Hepatology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":100,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"AbbVie","keywords":"Medicine; Ulcerative colitis; Calprotectin; Internal medicine; Gastroenterology; Odds ratio; Confidence interval; Janus kinase; Tofacitinib; Colitis; Vedolizumab; C-reactive protein; Inflammatory bowel disease; Disease; Inflammation; Cytokine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005911283,0.0002513169,0.0009193409,0.0001697071,0.0001094763,0.000265135,0.0002100034,0.0002073008,0.001058538],"category_scores_gemma":[0.000834397,0.00007559379,0.000289395,0.0001525565,0.0001434798,0.0001906179,0.0001374748,0.0006745038,0.0001426975],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002625485,"about_ca_system_score_gemma":0.0002835628,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000253373,"about_ca_topic_score_gemma":0.0008365394,"domain_scores_codex":[0.99975,0.00008796917,0.00002216975,0.00002857019,0.00005280937,0.00005858635],"domain_scores_gemma":[0.9996291,0.00008949428,0.0001533114,0.00002418073,0.00002882431,0.00007495848],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.1572206,0.01363506,0.06269167,0.00162143,0.001229431,0.0003476175,0.0002330189,0.003882185,0.136509,0.000166669,0.003947307,0.618516],"study_design_scores_gemma":[0.0311357,0.302597,0.5944929,0.000289786,0.001617413,0.001350576,0.0001405081,0.00529481,0.05680065,0.0001727946,0.00605694,0.00005082866],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970402,0.002055323,0.0001180218,0.00005889817,0.00001827603,0.00005258061,0.00007173661,0.00002930607,0.0005555935],"genre_scores_gemma":[0.9988161,0.0005361279,0.0001504548,0.00004495409,0.00002283966,0.00003290659,0.0001319852,0.000002461481,0.0002621688],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001058538,"threshold_uncertainty_score":0.003541172,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02161366859648141,"score_gpt":0.3134519652136321,"score_spread":0.2918382966171507,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}