{"id":"W4310505112","doi":"10.1016/j.smim.2022.101702","title":"What’s self got to do with it: Sources of heterogeneity among naive T cells","year":2022,"lang":"en","type":"review","venue":"Seminars in Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre; Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Biology; CD8; T cell; Cytotoxic T cell; T-cell receptor; Population; Repertoire; Naive T cell; Negative selection; Homogeneous; Immune system; Cell biology; Immunology; Genetics; Gene; In vitro; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008284189,0.0006827537,0.001308306,0.0009246798,0.000276941,0.001654968,0.0009136298,0.001612638,0.001957215],"category_scores_gemma":[0.0007967433,0.0002300463,0.0003945145,0.0007821054,0.001077147,0.002739273,0.0007186589,0.002702329,0.002380289],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008031043,"about_ca_system_score_gemma":0.0009373284,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005100629,"about_ca_topic_score_gemma":0.0006340799,"domain_scores_codex":[0.9997593,0.00004992837,0.00002486035,0.00005029512,0.00008254264,0.00003300218],"domain_scores_gemma":[0.9997134,0.0001196337,0.00002987162,0.00001542563,0.00007831767,0.00004334721],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001326299,0.0000399026,0.0001967678,0.008875268,0.00008402186,0.0003011019,0.0001149234,0.0002553572,0.003400488,0.01407046,0.06200891,0.9105201],"study_design_scores_gemma":[0.00001336815,0.00006819222,0.0004824144,0.00184134,0.0000364185,0.001156124,0.00008765647,0.00006050364,0.0006366844,0.006390248,0.9892113,0.00001581384],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001232848,0.9959067,0.0001879079,0.001355459,0.001453579,0.000002812948,0.00001202296,0.00000867604,0.0009495383],"genre_scores_gemma":[0.001471335,0.9936805,0.0002186046,0.001591465,0.001384888,0.000006937208,0.00002981123,0.000005426001,0.001610968],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001957215,"threshold_uncertainty_score":0.006547511,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01777212071124974,"score_gpt":0.2637586741563532,"score_spread":0.2459865534451035,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}