{"id":"W4310505112","doi":"10.1016/j.smim.2022.101702","title":"What’s self got to do with it: Sources of heterogeneity among naive T cells","year":2022,"lang":"en","type":"review","venue":"Seminars in Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre; Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Biology; CD8; T cell; Cytotoxic T cell; T-cell receptor; Population; Repertoire; Naive T cell; Negative selection; Homogeneous; Immune system; Cell biology; Immunology; Genetics; Gene; In vitro; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["research_integrity"],"category_scores_codex":[0.0008068237,0.001201061,0.004178945,0.001336796,0.0003139528,0.00004511549,0.002145215,0.001954311,0.002133292],"category_scores_gemma":[0.00008002,0.001021501,0.0006789877,0.001177515,0.001356341,0.000215882,0.001552032,0.002607782,0.000702714],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004281931,"about_ca_system_score_gemma":0.0005106708,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003003668,"about_ca_topic_score_gemma":0.0001998908,"domain_scores_codex":[0.9930655,0.002073503,0.001770789,0.001524634,0.0001232835,0.001442264],"domain_scores_gemma":[0.9957619,0.001117731,0.001254975,0.001714701,0.00009639174,0.00005432163],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0009600499,0.002485764,0.0006169826,0.005577944,0.007862755,0.0006738502,0.009589467,0.00002807049,0.03326902,0.0002786635,0.005001244,0.9336562],"study_design_scores_gemma":[0.001074471,0.001862087,0.00002056438,0.005733412,0.0006631741,0.0009657695,0.002635731,8.985774e-8,0.01306557,0.00002000802,0.9729732,0.0009858687],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.04469094,0.9481477,0.000003749104,0.00004351537,0.004659873,0.001597422,0.0001281775,0.0001156483,0.0006130178],"genre_scores_gemma":[0.002521124,0.9921204,0.0001402957,0.0001029509,0.0000371371,0.0006741385,0.0004257996,0.0001578972,0.00382022],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.967972,"threshold_uncertainty_score":0.9996932,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01777212071124974,"score_gpt":0.2637586741563532,"score_spread":0.2459865534451035,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}