{"id":"W4310516388","doi":"10.1093/neuonc/noac264","title":"Cerebrospinal fluid methylome-based liquid biopsies for accurate malignant brain neoplasm classification","year":2022,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"National Cancer Institute","keywords":"Cerebrospinal fluid; Pathology; Liquid biopsy; Neoplasm; Medicine; Computational biology; Biology; Cancer; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002536121,0.0009876861,0.0006710431,0.001292054,0.0003528945,0.001069035,0.0007086759,0.0006864023,0.001202444],"category_scores_gemma":[0.005949851,0.0003629503,0.0006467871,0.0005161423,0.0003736627,0.0006923091,0.0009432277,0.001002592,0.0007644952],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007304153,"about_ca_system_score_gemma":0.0009215341,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002453974,"about_ca_topic_score_gemma":0.005220517,"domain_scores_codex":[0.9991203,0.0003230512,0.00006334268,0.000225754,0.0001992711,0.00006827938],"domain_scores_gemma":[0.9981244,0.0009472698,0.0003726125,0.0001548593,0.0003026814,0.00009812825],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004214055,0.0005608739,0.4861472,0.0006858873,0.0007334441,0.0006955907,0.0004179744,0.0808908,0.1337539,0.0008919117,0.003867613,0.2871406],"study_design_scores_gemma":[0.0001118219,0.001131211,0.1150412,0.0002230674,0.0003309202,0.0009468033,0.0003138818,0.7770321,0.09545159,0.004021257,0.005320413,0.00007573018],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8661216,0.003633233,0.1231888,0.0004992186,0.00008112316,0.0003421398,0.003148654,0.001084927,0.001900295],"genre_scores_gemma":[0.9530997,0.0006369021,0.04234565,0.0001432499,0.00003948648,0.0001811743,0.002806074,0.00005884175,0.0006888892],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002536121,"threshold_uncertainty_score":0.01341242,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04875382338574128,"score_gpt":0.3331425577509179,"score_spread":0.2843887343651766,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}