{"id":"W4310525636","doi":"10.1089/can.2022.0090","title":"Cannabidiol Protects Striatal Neurons by Attenuating Endoplasmic Reticulum Stress","year":2022,"lang":"en","type":"article","venue":"Cannabis and Cannabinoid Research","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Unfolded protein response; Neuroprotection; Endoplasmic reticulum; ATF6; Cell biology; Neurodegeneration; Viability assay; Programmed cell death; Neurotrophic factors; Thapsigargin; Apoptosis; Chemistry; Biology; Pharmacology; Biochemistry; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts","research_integrity","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.003340536,0.0006232608,0.0008739061,0.0009712183,0.002932383,0.0003477212,0.0007934065,0.0002386201,0.001500567],"category_scores_gemma":[0.0009839981,0.0006056966,0.0003073165,0.002271926,0.001101289,0.0002340867,0.001721142,0.003958528,0.00004333931],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009342876,"about_ca_system_score_gemma":0.00250714,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003407924,"about_ca_topic_score_gemma":0.0002433054,"domain_scores_codex":[0.9897721,0.001277387,0.0008479964,0.001758758,0.00369937,0.002644327],"domain_scores_gemma":[0.9958538,0.00004330428,0.0001924339,0.001280168,0.001079174,0.001551097],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005143994,0.0005770337,0.004433644,0.0004954301,0.0001001935,0.0004418237,0.0009143204,0.00006769956,0.04881366,0.0003722343,0.9307244,0.0125452],"study_design_scores_gemma":[0.003753165,0.003561247,0.01346732,0.0001019246,0.00006817958,0.0007354741,0.005911312,0.001032014,0.03440952,0.0001469677,0.9359557,0.0008571466],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9176177,0.00364718,0.00001688007,0.06913143,0.0003808505,0.00372641,0.001195759,0.0001912592,0.004092503],"genre_scores_gemma":[0.8413153,0.0002446844,0.00004003818,0.0008324787,0.0004625039,0.004645441,0.0003741063,0.0002085138,0.1518769],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1477844,"threshold_uncertainty_score":0.9996395,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02703862635364461,"score_gpt":0.3192619815996993,"score_spread":0.2922233552460546,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}