{"id":"W4310535300","doi":"10.3389/fmolb.2022.1054408","title":"Cellular functions of the ClpP protease impacting bacterial virulence","year":2022,"lang":"en","type":"review","venue":"Frontiers in Molecular Biosciences","topic":"Bacterial Genetics and Biotechnology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; University of Toronto","keywords":"Virulence; Biology; Protease; Proteostasis; Proteases; Effector; Chaperone (clinical); AAA proteins; Cell biology; Serine protease; CLPB; ATPase; Biofilm; Microbiology; Bacteria; Enzyme; Heat shock protein; Biochemistry; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004746857,0.0003460623,0.0006546574,0.0002132861,0.0001898666,0.00004209403,0.00137697,0.0004616527,0.00004792519],"category_scores_gemma":[0.000241421,0.0002491914,0.0004629162,0.000871545,0.000571907,0.000004049009,0.0007788695,0.0003803904,0.000001857394],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005372435,"about_ca_system_score_gemma":0.0006047843,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000301165,"about_ca_topic_score_gemma":0.000006138252,"domain_scores_codex":[0.9976517,0.0003765989,0.0005574896,0.000710643,0.0002979411,0.0004056492],"domain_scores_gemma":[0.9985957,0.000009262595,0.0005154815,0.0007892317,0.00002731549,0.00006302716],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004184919,0.0002099749,0.0002239724,0.001534022,0.0001902322,0.00001859818,0.00002898742,0.00001729676,0.4451517,0.00003763389,0.001561203,0.5509846],"study_design_scores_gemma":[0.0001168519,0.0002009984,0.000005754084,0.0003130332,0.0001265609,0.00001075925,0.00005967436,0.00000543296,0.0307393,0.00002876908,0.9680876,0.0003052804],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.006986038,0.9858758,0.001105971,0.00003866214,0.004723343,0.0009910158,0.0001735893,0.00001019059,0.00009541483],"genre_scores_gemma":[0.001453087,0.9958515,0.002001993,0.00003496918,0.0001906313,0.0001537412,0.0001550079,0.00003886801,0.0001202635],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9665264,"threshold_uncertainty_score":0.999996,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01467780795679627,"score_gpt":0.2533343076980255,"score_spread":0.2386564997412292,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}