{"id":"W4310539748","doi":"10.1016/j.xpro.2022.101894","title":"In vitro and in cellulo ApoE particle formation, isolation, and characterization","year":2022,"lang":"en","type":"article","venue":"STAR Protocols","topic":"Lipid Membrane Structure and Behavior","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Ontario Institute for Regenerative Medicine; Universität Zürich; Université de Genève; Eidgenössische Technische Hochschule Zürich; Louis-Jeantet Foundation; European Molecular Biology Laboratory; AbbVie","keywords":"Particle (ecology); In vitro; Scattering; Immunoprecipitation; Apolipoprotein E; Membrane; Characterization (materials science); Dynamic light scattering; Chemistry; Biophysics; Light scattering; Fatty acid; Isolation (microbiology); Chemical engineering; Chromatography; Biochemistry; Chemical physics; Materials science; Nanotechnology; Gene; Physics; Optics; Biology; Bioinformatics; Nanoparticle; Engineering","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000120089,0.00005602485,0.0000620812,0.00002889374,0.00005189618,0.00001523169,0.00003561062,0.0000279761,0.00002668725],"category_scores_gemma":[0.000007437799,0.00005680851,0.000007748725,0.00007491493,0.00001521595,0.00001503618,0.00006495789,0.00005374789,3.837771e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001044533,"about_ca_system_score_gemma":0.00001830795,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007597163,"about_ca_topic_score_gemma":0.00001464513,"domain_scores_codex":[0.9995207,0.00005117613,0.0001374787,0.0001356399,0.00005594093,0.00009902861],"domain_scores_gemma":[0.9998404,0.000002224494,0.00003895799,0.00008326411,0.00001302043,0.00002217413],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001590959,0.00002412951,0.006720656,0.00002133876,8.580653e-7,0.00000110411,0.0002127075,0.000003162188,0.9918706,0.00001295424,0.00001421989,0.0009591025],"study_design_scores_gemma":[0.0009596719,0.0001088173,0.02919065,0.000004023865,0.000001735289,0.000008698116,0.00007524178,0.0002317577,0.9541345,0.0000423261,0.0151567,0.00008583257],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9902685,0.000006760751,0.0000678372,0.0001531913,0.00001610138,0.009443281,0.0000212485,0.000003326022,0.00001975731],"genre_scores_gemma":[0.9830433,0.000002874195,0.000101978,0.0001705984,0.00003537081,0.01642017,0.0001270248,0.000006069157,0.00009267963],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03773613,"threshold_uncertainty_score":0.2316584,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01001569814673187,"score_gpt":0.260146938144888,"score_spread":0.2501312399981561,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}