{"id":"W4310546590","doi":"10.3389/fimmu.2022.1007718","title":"Interferon-inducible SAMHD1 restricts viral replication through downregulation of lipid synthesis","year":2022,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital","funders":"","keywords":"SAMHD1; Biology; Viral replication; Gene silencing; Interferon; Virology; RNA interference; Gene; Virus; RNA; Genetics; Reverse transcriptase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001171116,0.0002964445,0.0001695147,0.0001691173,0.000179877,0.0002056265,0.0001500457,0.0001654078,0.001822602],"category_scores_gemma":[0.0000826552,0.00008717469,0.0002108929,0.0001133485,0.0001891014,0.0001505838,0.0002071417,0.0003517195,0.0004950216],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002835625,"about_ca_system_score_gemma":0.0001640058,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002046807,"about_ca_topic_score_gemma":0.000393709,"domain_scores_codex":[0.9998995,0.00001088919,0.000007406293,0.00003231341,0.00002348495,0.00002639135],"domain_scores_gemma":[0.9998983,0.00001638031,0.00003144957,0.00001179415,0.00001637318,0.00002567721],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006219499,0.00000765165,0.000250935,0.0000357662,0.000002400216,0.00001635863,0.000004706319,0.0000199282,0.9987887,0.00004975751,0.00003787107,0.0007238181],"study_design_scores_gemma":[0.000009282138,0.000106073,0.007931144,0.000007414806,0.00001143642,0.0001128475,0.00001789954,0.0005239235,0.9875272,0.00006114456,0.003688393,0.000003284857],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9868155,0.004762157,0.004520614,0.0001704983,0.00007625023,0.00002406116,0.00094508,0.0001869372,0.002498863],"genre_scores_gemma":[0.9938071,0.0009348649,0.00195384,0.00005465936,0.00002120812,0.00002270082,0.0009480608,0.00001914805,0.002238239],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001822602,"threshold_uncertainty_score":0.006097198,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01469968263482405,"score_gpt":0.2428339506747872,"score_spread":0.2281342680399631,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}