{"id":"W4310565736","doi":"10.1002/cbic.202200619","title":"Synthesis of Uronic Acid 1‐Azasugars as Putative Inhibitors of α‐Iduronidase, β‐Glucuronidase and Heparanase**","year":2022,"lang":"en","type":"article","venue":"ChemBioChem","topic":"Carbohydrate Chemistry and Synthesis","field":"Chemistry","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"Biotechnology and Biological Sciences Research Council; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Australian Research Council; University of Queensland; Royal Society","keywords":"Heparanase; Chemistry; Glucuronic acid; Iduronic acid; Biochemistry; Uronic acid; Glucuronidase; Glucuronidation; Stereochemistry; Enantiomer; Glycosyltransferase; Enzyme; Glycosaminoglycan; Heparan sulfate","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001766988,0.0005136756,0.0003878414,0.0002219585,0.000137789,0.0002340039,0.0004068197,0.0002617462,0.0009854814],"category_scores_gemma":[0.0001428997,0.0001639689,0.0002632875,0.0001931564,0.0001211392,0.000189127,0.0001775761,0.0003275275,0.0004322174],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003008839,"about_ca_system_score_gemma":0.0002668112,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005247844,"about_ca_topic_score_gemma":0.0007927223,"domain_scores_codex":[0.9998997,0.00002421373,0.00001195684,0.00001828724,0.0000168424,0.0000290239],"domain_scores_gemma":[0.9999299,0.00000992672,0.00001765387,0.00000718037,0.00001108671,0.00002423155],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003392993,0.0001183323,0.0001453099,0.000158489,0.00003826667,0.0002338948,0.0000507201,0.001212931,0.986927,0.001084316,0.0002480888,0.009443348],"study_design_scores_gemma":[0.0001161931,0.001439033,0.000577593,0.0000141061,0.00003893767,0.0002325888,0.00001967476,0.001503149,0.9876534,0.0001300754,0.008256521,0.00001866485],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.965113,0.0107768,0.01155275,0.0002026807,0.0002047533,0.0003067464,0.0009673331,0.0002641091,0.01061162],"genre_scores_gemma":[0.9861358,0.004206491,0.006066215,0.0000611891,0.00002542094,0.00007134736,0.0005664389,0.00003177968,0.002835338],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009854814,"threshold_uncertainty_score":0.003296733,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006458789711613521,"score_gpt":0.2106499588762646,"score_spread":0.2041911691646511,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}