{"id":"W4310565736","doi":"10.1002/cbic.202200619","title":"Synthesis of Uronic Acid 1‐Azasugars as Putative Inhibitors of α‐Iduronidase, β‐Glucuronidase and Heparanase**","year":2022,"lang":"en","type":"article","venue":"ChemBioChem","topic":"Carbohydrate Chemistry and Synthesis","field":"Chemistry","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"Biotechnology and Biological Sciences Research Council; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Australian Research Council; University of Queensland; Royal Society","keywords":"Heparanase; Chemistry; Glucuronic acid; Iduronic acid; Biochemistry; Uronic acid; Glucuronidase; Glucuronidation; Stereochemistry; Enantiomer; Glycosyltransferase; Enzyme; Glycosaminoglycan; Heparan sulfate","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002652924,0.0003380045,0.0006002458,0.00008823877,0.0001702139,0.0000155651,0.0003814039,0.0001405024,0.002529056],"category_scores_gemma":[0.0004569161,0.0003836729,0.0002563538,0.0003432835,0.0004038778,0.00007655555,0.0003930851,0.0003283216,0.000006253328],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001623195,"about_ca_system_score_gemma":0.0001968617,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007431119,"about_ca_topic_score_gemma":0.000001581649,"domain_scores_codex":[0.9979139,0.00004630309,0.0006134934,0.0005612655,0.0004829936,0.0003820299],"domain_scores_gemma":[0.998334,0.0003689293,0.0004414439,0.0005904068,0.00009371525,0.0001715397],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001791575,0.0002806155,0.0003735248,0.0006422606,0.000163036,0.00002478465,0.0006271145,0.00001924681,0.9949614,0.0001063243,0.0002229675,0.002399604],"study_design_scores_gemma":[0.0005145879,0.00005107891,0.00002936774,0.00007840855,0.0001488014,0.00004795691,0.002717501,0.00006053894,0.9946508,0.0002258852,0.001126061,0.0003489795],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9744587,0.00162042,0.000001924659,0.0001259059,0.00004495035,0.00008681786,0.0003588266,0.000052569,0.02324991],"genre_scores_gemma":[0.9986776,0.00007886601,0.00007990299,0.0000292055,0.00005433834,0.000122696,0.00006431375,0.00005124943,0.0008418226],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02421893,"threshold_uncertainty_score":0.9998615,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006458789711613521,"score_gpt":0.2106499588762646,"score_spread":0.2041911691646511,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}