{"id":"W4310566124","doi":"10.1093/g3journal/jkac301","title":"Development and applications of a CRISPR activation system for facile genetic overexpression in <i>Candida albicans</i>","year":2022,"lang":"en","type":"article","venue":"G3 Genes Genomes Genetics","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University of Guelph","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Burroughs Wellcome Fund","keywords":"Biology; CRISPR; Candida albicans; Genetic screen; Genome editing; Genetics; Computational biology; Microbiology; Gene; Phenotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004403785,0.0004827299,0.0002965921,0.0003656649,0.0004026744,0.0006116617,0.0005896594,0.0006031311,0.001476341],"category_scores_gemma":[0.0002808285,0.0003346641,0.0004634764,0.0002078266,0.0002918249,0.0002240813,0.000497127,0.000981048,0.0008740649],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004707952,"about_ca_system_score_gemma":0.000718803,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00134343,"about_ca_topic_score_gemma":0.001787002,"domain_scores_codex":[0.9995539,0.00005714736,0.00006103253,0.0001099494,0.0001610604,0.00005686091],"domain_scores_gemma":[0.9998115,0.00003456511,0.00004675914,0.00003746511,0.00003279103,0.00003699891],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002903776,0.00001735474,0.00009286626,0.00003985977,0.000003897861,0.00006079878,0.00001791891,0.0002773482,0.9949538,0.0003182546,0.000140545,0.004048221],"study_design_scores_gemma":[0.000008143762,0.0001022855,0.000613066,0.000008943251,0.00000836318,0.0002591037,0.00001249969,0.001684259,0.9911527,0.00005616994,0.006081492,0.00001290451],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6095709,0.002449704,0.3629897,0.001220977,0.0003212591,0.001384258,0.00374373,0.004403766,0.01391562],"genre_scores_gemma":[0.7112876,0.001831678,0.2745495,0.0003140686,0.00003191558,0.0006885483,0.002486969,0.0003702256,0.008439405],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001476341,"threshold_uncertainty_score":0.0049389,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01719991413771275,"score_gpt":0.2658366911167228,"score_spread":0.24863677697901,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}