{"id":"W4310567029","doi":"10.1021/acs.analchem.2c03315","title":"Sequential Reagent Release from a Layered Tablet for Multistep Diagnostic Assays","year":2022,"lang":"en","type":"article","venue":"Analytical Chemistry","topic":"Biosensors and Analytical Detection","field":"Engineering","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; Temerty Faculty of Medicine, University of Toronto; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Reagent; Chemistry; Microcrystalline cellulose; Chromatography; Cellulose; Sample preparation; Hydroxypropyl cellulose; Combinatorial chemistry; Polymer; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001114217,0.001173905,0.0008755103,0.0007076969,0.0002580893,0.0009275852,0.001065754,0.00124196,0.002067618],"category_scores_gemma":[0.001702832,0.0007546843,0.0007461022,0.0004027948,0.0003576731,0.0008782269,0.0005592795,0.001454157,0.001388027],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003779626,"about_ca_system_score_gemma":0.0003234041,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000467788,"about_ca_topic_score_gemma":0.0007108888,"domain_scores_codex":[0.9983478,0.0002018515,0.0001799638,0.0003811948,0.0007891988,0.000100067],"domain_scores_gemma":[0.9988487,0.0004161881,0.0002902235,0.0001532511,0.0001877517,0.0001039472],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009533128,0.00006564113,0.0001355956,0.0002373342,0.0000228507,0.00007281987,0.00003257408,0.0001399851,0.9881437,0.0001235904,0.0003503046,0.01058029],"study_design_scores_gemma":[0.00003916396,0.0006020019,0.0008457144,0.00002743898,0.00006426585,0.0003068699,0.00001837417,0.004167696,0.9870357,0.0000593629,0.006790838,0.00004249995],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.3637427,0.009967173,0.6062677,0.0007468208,0.0006883861,0.003505582,0.001879449,0.006197682,0.007004393],"genre_scores_gemma":[0.4601181,0.004038202,0.5234062,0.0006905216,0.000164009,0.001774784,0.001347183,0.0004442931,0.008016652],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.002067618,"threshold_uncertainty_score":0.006916881,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01330312185910987,"score_gpt":0.2176631204762283,"score_spread":0.2043599986171184,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}