{"id":"W4310572161","doi":"10.1126/sciadv.adc9851","title":"Stimulation of RAS-dependent ROS signaling extends longevity by modulating a developmental program of global gene expression","year":2022,"lang":"en","type":"article","venue":"Science Advances","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institutes of Health","keywords":"Superoxide; Reactive oxygen species; Biology; Cell biology; Superoxide dismutase; Caenorhabditis elegans; Gene; Mitochondrion; Gene expression; Drosophila melanogaster; Stimulation; Signal transduction; Regulation of gene expression; Biochemistry; Oxidative stress; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007136272,0.000318369,0.0001637009,0.0001807864,0.0001032625,0.000220595,0.0001325978,0.0001750944,0.001051663],"category_scores_gemma":[0.00005666455,0.00008821581,0.0001973014,0.00008855345,0.0001728832,0.000129624,0.0001580129,0.0003182398,0.000223223],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001687663,"about_ca_system_score_gemma":0.000133645,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001787136,"about_ca_topic_score_gemma":0.0004412382,"domain_scores_codex":[0.9999462,0.000009828762,0.000004936634,0.00001587158,0.0000132024,0.000009954337],"domain_scores_gemma":[0.9999053,0.00001384222,0.00003092874,0.00001314754,0.000009650312,0.00002718365],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004697203,0.000007627932,0.0000723807,0.000007501468,0.000001367524,0.00001017073,0.000003125354,0.00001932804,0.9992798,0.00004179971,0.000006055861,0.0005039491],"study_design_scores_gemma":[0.000005921249,0.0002988545,0.00250486,0.000002382481,0.000009010462,0.000104207,0.00001060414,0.000314621,0.9953668,0.00004748744,0.001332846,0.000002451675],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958465,0.000699855,0.001973253,0.00007720958,0.00002103927,0.000009757176,0.0001805289,0.0001005462,0.00109135],"genre_scores_gemma":[0.9946319,0.0006458532,0.002181682,0.00002802827,0.000009134676,0.00001438456,0.0002411398,0.00001719451,0.002230699],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001051663,"threshold_uncertainty_score":0.003518164,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009677652906940315,"score_gpt":0.2805347166479862,"score_spread":0.2708570637410458,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}