{"id":"W4310573307","doi":"10.1080/19420862.2022.2149057","title":"A glyco-engineering approach for site-specific conjugation to Fab glycans","year":2022,"lang":"en","type":"article","venue":"mAbs","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada","funders":"National Research Council Canada","keywords":"Chemistry; Glycan; Epitope; Antibody-drug conjugate; Glycosylation; Monoclonal antibody; Linker; Combinatorial chemistry; Antibody; Drug; Glycoprotein; Biochemistry; Pharmacology; Biology; Computer science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001831333,0.00009336834,0.0001588634,0.00012213,0.0001705343,0.00001717837,0.00009039938,0.00002311966,0.0004826736],"category_scores_gemma":[0.00003377675,0.00008645304,0.00008358924,0.000215669,0.00001349703,0.00001901489,0.0001030409,0.0001729255,0.00004955465],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001026019,"about_ca_system_score_gemma":0.00003428202,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005338894,"about_ca_topic_score_gemma":0.000001826056,"domain_scores_codex":[0.9990267,0.00001509311,0.0001406588,0.0002209342,0.0003321958,0.0002643865],"domain_scores_gemma":[0.9995666,0.00006301643,0.00001740104,0.0001525248,0.00005950132,0.0001409821],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0126611,0.001388863,0.01329844,0.001855501,0.0003537734,0.0002316398,0.005507205,0.02645031,0.4957888,0.05114808,0.3413258,0.04999042],"study_design_scores_gemma":[0.0009837097,0.0006312114,0.003389188,0.00001146382,0.00001351821,0.00006365234,0.0002487757,0.01674939,0.001658575,0.00004525291,0.9760556,0.0001496161],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.95916,0.0005968545,0.0226475,0.006873783,0.0002980041,0.001699259,0.000274665,0.0001288137,0.008321153],"genre_scores_gemma":[0.9717376,0.00001535084,0.01073388,0.0008352564,0.0003875133,0.0005599817,0.0004731614,0.00003275711,0.01522453],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6347298,"threshold_uncertainty_score":0.5284938,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03186125103665228,"score_gpt":0.2829580887410076,"score_spread":0.2510968377043553,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}